Projects
RT 20/4 ALTERTOX - Towards risk assessment of Alternaria mycotoxins: comparative in vitro toxicity, and in vivo toxicokinetics in pigs as surrogate animal model for humans Ghent University
ALTERTOX aims to clarify following research questions:
- What is the in vitro cytotoxicity of alternariol, alternariol-monomethylether, tenuazonic acid and relevant mixtures thereof towards intestinal epithelial cells and hepatocytes of human and porcine origin? This will enable the calculation of the mycotoxin concentration at which 50% of the cells show loss in viability (EC50 endpoint), and to determine the ...
Therapeutic application of multipotent stem cells in an animal model of multiple sclerosis Hasselt University
Prosthetic heart valve thrombosis: development of a large animal model and new strategies towards prevention. KU Leuven
In recent long-term follow-up studies of patients after heart valve replacement surgery, mechanical valves still provide excellent outcomes. Mechanical valves are durable and can function for decades without structural deterioration or wear. The most important drawback of mechanical heart valves however, is their tendency to provoke thrombosis at the surface of the valve, causing either valve dysfunction or thrombo-embolic events to ...
The septual nucleus neurocircuitry in an animal model for anorexia nervosa. KU Leuven
Development of an extended animal model for perinatal drug testing for Bronchopulmonary Dysplasia KU Leuven
Premature birth affects 11% of all pregnancies and is the leading cause of death in neonates worldwide. Advances in perinatal medicine have resulted in the more accurate prediction of preterm birth and more timely interventions leading to increased neonatal survival rates also for extreme preterm babies (≤28 weeks). However, the associated morbidity in survivors remains significant, especially in the pulmonary and central nervous system. At ...
Interaction between Fusarium mycotoxins and cytochrome P450 drug metabolizing enzymes and ABC drug transporters in a porcine animal model Ghent University
Mycotoxins are feed and food contaminants which can modulate the expression of genes encoding for CYP450 enzymes and ABC drug transporters and/or may modulate their activity. The goal of this research proposal is to investigate the effect of mycotoxin intake on the pharmacokinetic behavior of CYP450 and ABC substrate drugs in a pig animal model.