A functional role of gelatinase A in the development of nutritionally induced obesity in mice KU Leuven
BACKGROUND: Development of adipose tissue is a complex process involving adipogenesis, angiogenesis and proteolytic remodeling of the extracellular matrix. The matrix metalloproteinase (MMP) system plays an important role in these processes. OBJECTIVE: To establish a functional role of gelatinase A (MMP-2) in the development of adipose tissue. METHODS: Mice with genetic deficiency in gelatinase A (MMP-2(-/-)) and their wild-type littermates ...