Projects
Finding new treatments for diseases where angiogenesis is insufficient such as ischemic stroke, wound healing and pulp regeneration. Hasselt University
RESPONSE PREDICTION IN METASTATIC RENAL CELL CARCINOMA TREATED WITH ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR TARGETED THERAPY AND/OR IMMUNE CHECKPOINT INHIBITORS KU Leuven
A better understanding of Protein Kinase D structure and regulation serving the development of innovative anti-cancer kinase inhibitors. KU Leuven
Identification of novel chemokine receptor inhibitors for anti-cancer therapy KU Leuven
Endothelial cell metabolism blockade to induce tumor vessel normalization and improve immunotherapy KU Leuven
Traditional anti-angiogenesis strategies attempt to prune tumor vessels. However, their success is restricted by toxicity and resistance. There is thus an unmet need for new anti-angiogenic strategies with fundamentally distinct mechanisms. An alternative therapeutic paradigm is tumor vessel normalization (TVN). By healing disorganized vessels, TVN improves perfusion and oxygenation, tightens the leaky vascular wall, thus reducing metastasis ...
Stabilization of atherosclerotic plaques via inhibition of intraplaque neovascularization. University of Antwerp
Preclinical investigation of immunotherapy and VEGF-targeted therapy in combination with voluntary exercise as novel treatment strategy for malignant pleural mesothelioma. University of Antwerp
Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy Ghent University
Autophagy is crucial in the (patho)physiology, including inflammation, infection and cancer. Autophagy functions as a survival mechanism by maintaining viability during periods of stress, and by removing damaged organelles and toxic metabolites, such as protein aggregates or intracellular pathogens. The Atlantis research consortium (AuTophagy in InfLAmmatioN and inflammaTory dISorders) brings together a team of expert investigators from the ...
Discovery of novel growth control and cancer mechanisms KU Leuven
The objectives of my research are 1) to discover signaling mechanisms that regulate cell proliferation during organ growth and regeneration, 2) to understand how signaling pathways cooperate to produce a cancerous state, and 3) to discover vulnerabilities of cancer cells (synthetic lethal genes) that could provide novel approaches for cancer therapy.