1 - 10 of 170 results
Four layer multi-omics reveals molecular responses to aneuploidy in Leishmania Hasselt University Institute of Tropical Medicine
Chemically induced aneuploidy in germ cells. Part II of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases Vrije Universiteit Brussel
As part of the 7th International Workshops on Genotoxicity Testing held in Tokyo, Japan in November 2017, a workgroup of experts reviewed and assessed the risk of aneugens for human health. The present manuscript is one of three manuscripts from the workgroup and reports on the unanimous consensus reached on the evidence for aneugens affecting germ cells, their mechanisms of action and role in hereditary diseases. There are 24 chemicals with ...
Preimplantation genetic testing for aneuploidy by microarray analysis of polar bodies in advanced maternal age Vrije Universiteit Brussel
STUDY QUESTION: Does preimplantation genetic testing for aneuploidy (PGT-A) by comprehensive chromosome screening (CCS) of the first and second polar body to select embryos for transfer increase the likelihood of a live birth within 1 year in advanced maternal age women aged 36-40 years planning an ICSI cycle, compared to ICSI without chromosome analysis?
SUMMARY ANSWER: PGT-A by CCS in the first and second polar body to select euploid ...
Analysis of parental contribution for aneuploidy detection (APCAD) Vrije Universiteit Brussel
RESEARCH QUESTION: Can (mosaic) aneuploidy be reliably detected in preimplantation embryos after multiple displacement amplification and single nucleotide polymorphism detection, independent of haplotyping and copy number detection, with a new method 'analysis of parental contribution for aneuploidy detection' or 'APCAD'?
DESIGN: This method is based on the maternal contribution, a parameter that reflects the proportion of DNA that is ...
Higher limb asymmetry in deceased human fetuses and infants with aneuploidy University of Antwerp
Evolution of aneuploidy up to Day 4 of human preimplantation development Vrije Universiteit Brussel
Summary answer: Our data show extensive abnormalities in Day-4 embryos.
What is known already: Numerous studies on human embryos at Day 3 and Day 5 of development show that they frequently contain aneuploid cells and are mosaic, although Day-5 embryos ...