Publications
Chemically induced aneuploidy in germ cells. Part II of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases Vrije Universiteit Brussel
As part of the 7th International Workshops on Genotoxicity Testing held in Tokyo, Japan in November 2017, a workgroup of experts reviewed and assessed the risk of aneugens for human health. The present manuscript is one of three manuscripts from the workgroup and reports on the unanimous consensus reached on the evidence for aneugens affecting germ cells, their mechanisms of action and role in hereditary diseases. There are 24 chemicals with ...
Investigating aneuploidy and mosaicism as a mechanism for survival and adaptation of Leishmania Institute of Tropical Medicine
Investigating aneuploidy and mosaicism as a mechanism for survival and adaptation of Leishmania University of Antwerp
Four layer multi-omics reveals molecular responses to aneuploidy in Leishmania University of Antwerp Institute of Tropical Medicine Hasselt University
Role of aneuploidy in the carcinogenic process Vrije Universiteit Brussel
Aneuploidy is regarded as a hallmark of cancer, however, its role is complex with both pro- and anti-carcinogenic effects evident. In this IWGT review, we consider the role of aneuploidy in cancer biology; cancer risk associated with constitutive aneuploidy; rodent carcinogenesis with known chemical aneugens; and chemotherapy-related malignant neoplasms. Aneuploidy is seen at various stages in carcinogenesis. However, the relationship between ...
Risks of aneuploidy induction from chemical exposure Vrije Universiteit Brussel
Although Theodor Boveri linked abnormal chromosome numbers and disease more than a century ago, an in-depth understanding of the impact of mitotic and meiotic chromosome segregation errors on cell proliferation and diseases is still lacking. This review reflects on the efforts and results of a large European research network that, from the 1980's until 2004, focused on protection against aneuploidy-inducing factors and tackled the following ...
Targets and mechanisms of chemically induced aneuploidy. Part 1 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases Vrije Universiteit Brussel
An aneuploidy workgroup was established as part of the 7th International Workshops on Genotoxicity Testing. The workgroup conducted a review of the scientific literature on the biological mechanisms of aneuploidy in mammalian cells and methods used to detect chemical aneugens. In addition, the current regulatory framework was discussed, with the objective to arrive at consensus statements on the ramifications of exposure to chemical aneugens ...
Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania Institute of Tropical Medicine
An economic analysis of preimplantation genetic testing for aneuploidy by polar body biopsy in advanced maternal age Vrije Universiteit Brussel
OBJECTIVE: What are the cost per live birth and the incremental cost of preventing a miscarriage with preimplantation genetic testing for aneuploidy (PGT-A) by polar body biopsy and array-based comprehensive genome hybridisation (aCGH) versus regular IVF/ICSI without PGT-A for infertility treatment in women 36-40 years of age?
DESIGN: Decision tree model.
POPULATION: A randomised clinical trial on PGT-A (ESTEEM study).
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