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Epidemiological and clinicopathological features of anaplasma phagocytophilum infection in dogs : a systematic review Ghent University

Sarah El Hamiani Khatat, Sylvie Daminet, Luc Duchateau, Latifa El Hachimi, Malika Kachani, Hamid Sahibi
Anaplasma phagocytophilum is a worldwide emerging zoonotic tick-borne pathogen transmitted by Ixodid ticks and naturally maintained in complex and incompletely assessed enzootic cycles. Several studies have demonstrated an extensive genetic variability with variable host tropisms and pathogenicity. However, the relationship between genetic diversity and modified pathogenicity is not yet understood. Because of their proximity to humans, dogs are ...

Host specificity, pathogen exposure, and superinfections impact the distribution of Anaplasma phagocytophilum genotypes in ticks, roe deer, and livestock in a fragmented agricultural landscape University of Antwerp

Amélie Chastagner, Angelique Pion, Helene Verheyden, Bruno Lourtet, Bruno Cargnelutti, Denis Picot, Valerie Poux, Emilie Bard, Olivier Plantard, Karen D. McCoy, et al.
Anaplasma phagocytophilum is a bacterial pathogen mainly transmitted by Ixodes ricinus ticks in Europe. It infects wild mammals, livestock, and, occasionally, humans. Roe deer are considered to be the major reservoir, but the genotypes they carry differ from those that are found in livestock and humans. Here, we investigated whether roe deer were the main source of the A. phagocytophilum genotypes circulating in questing I. ricinus nymphs in a ...

Using Serum Specimens for Real-Time PCR-Based Diagnosis of Human Granulocytic Anaplasmosis, Canada Institute of Tropical Medicine

Carl Gregory Boodman, Courtney Loomer, Antonia Dibernardo, Todd Hatchette, Jason J LeBlanc, Brooks Waitt, L Robbin Lindsay

Whole blood is the optimal specimen for anaplasmosis diagnosis but might not be available in all cases. We PCR tested serum samples collected in Canada for Anaplasma serology and found 84.8%-95.8% sensitivity and 2.8 average cycle threshold elevation. Serum can be acceptable for detecting Anaplasma spp. when whole blood is unavailable.

Circulation of four **Anaplasma phagocytophilum** ecotypes in Europe University of Antwerp

Setareh Jahfari, E. Claudia Coipan, Manoj Fonville, Dieter Heylen, et al.
Background Anaplasma phagocytophilum is the etiological agent of granulocytic anaplasmosis in humans and animals. Wild animals and ticks play key roles in the enzootic cycles of the pathogen. Potential ecotypes of A. phagocytophilum have been characterized genetically, but their host range, zoonotic potential and transmission dynamics has only incompletely been resolved. Methods The presence of A. phagocytophilum DNA was determined in more than ...

Prevalence of **Neoehrlichia mikurensis** in ticks and rodents from North-west Europe University of Antwerp

Setareh Jahfari, Manoj Fonville, Paul Hengeveld, Chantal Reusken, Ernst-Jan Scholte, Willem Takken, Paul Heyman, Jolyon M. Medlock, Dieter Heylen, Jenny Kleve, et al.
Background: Neoehrlichia mikurensis s an emerging and vector-borne zoonosis: The first human disease cases were reported in 2010. Limited information is available about the prevalence and distribution of Neoehrlichia mikurensis in Europe, its natural life cycle and reservoir hosts. An Ehrlichia-like schotti variant has been described in questing Ixodes ricinus ticks, which could be identical to Neoehrlichia mikurensis. Methods: Three genetic ...