Projects
COIN-B: COntrolled Interruption of Nucleos(t)ide analogue treatment in chronic hepatitis B. University of Antwerp
Vapour deposition of metal-organic graphene analogue nanofilms for memory devices KU Leuven
The rapid advancement of the digital era requires novel materials and device concepts for data storage. Memristors are a promising class of memory devices in which information is stored and extracted as changes in the electrical resistance of a storage medium. So far, the working principle and potential of memristors have been illustrated only using readily available ‘off-the-shelf’ materials and components. However, to reach the ...
A new approach to assess geothermal reservoir potential: An integrated core and analogue study for the Buntsandstein Formation of the Campine Basin (NE Belgium) KU Leuven
Geothermal energy can allow Flanders to make the transition towards a sustainable and low-carbon economy, either through the production of geothermal electricity or heat. Geothermal reservoirs in Flanders are either made of siliciclastic sediments or carbonate rocks, of which the former will be investigated during this research. In general, this project focuses on siliciclastic geothermal reservoirs, which are suitable for low-temperature ...
Using cold-water coral mini-mounds as analogue for giant mound growth: assessment of environmental drivers and anthropogenic impact (MINIMOUND) Ghent University
The MINIMOUND project aims to study the initiation, growth and demise of cold-water coral mounds in relationship with climatic and hydrocarbon-seepage related processes. This study will focus on three provinces of mounds along the Biscay margin. In the first place, we aim to establish a chronostratigraphic framework and decipher the palaeoceanographic changes within the last 15000 years
Analogue modelling of morpho-structural processes in active volcano-tectonic regions Vrije Universiteit Brussel
Analogue synthesis and structural elucidation of natural products with antiviral activities. KU Leuven
Insight into the contribution of proteins, fats and ingredients to the structure and physical stability of vegetarian meat analogues KU Leuven
Despite growing consumer interest in protein-rich alternatives to meat products, plant-based emulsified meat analogues often have sub-optimal texture compared to the meat products they imitate. This is partly due to the knowledge gap on the structure formation, techno-functional characteristics and underlying mechanisms of nontexturized proteins used. These questions are addressed by describing the influence and underlying mechanisms of plant ...
A dance with palladium: exploration of propargylguanidines in tandem cyclization / C-H activation processes for the synthesis of kealiinine analogues and related medium-rings. KU Leuven
The new alkaloids kealiininesA-C, isolated in 2004 by Proksch and co-workers from the marine sponge Leucetta chagosensis, display a typical 2-aminoimidazole skeleton.They have been shown to posses a naphthimidazole moiety, which could be regarded as a conformationally constrained variant of the related naami(di)ne alkaloids, which possess interesting pharmaceutical properties. Although kealiinineA showed promising bioactivity, no profound ...
Development of new antibiotics: Synthesis of innovative aminoacylated sulfonamide nucleosides and mupirocin analogues as aminoacyl-tRNA-synthetase inhibitors KU Leuven
The alarming spread of bacterial resistance to existing antibiotics is a serious global health threat. As a result, there is an urgent need for new antibiotics which preferably act on new cellular targets that are essential for the survival of pathogens. The toxicity, selectivity, bioavailability in patients, the serum stability and, in particular, the bacterial uptake are important challenges in the development of new antibiotics.
The ...