Publications
Lymphoblast-derived integration-free iPSC lines from a female and male Alzheimer's disease patient expressing different copy numbers of a coding CNV in the Alzheimer risk gene CR1 University of Antwerp
The Alzheimer case : perceptions, knowledge, and the acquisition of information about Alzheimer’s disease by the general public (50+) in Flanders Ghent University
Synchronisation sensorimotrice et comportements non verbaux dans la maladie d’Alzheimer : l’influence du contexte social et musical = Sensorimotor synchronization and non-verbal behaviors in Alzheimer's disease : the influence of social and musical contex Ghent University
Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia Vrije Universiteit Brussel University of Antwerp
BACKGROUND: Neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease with dementia (PDD), and dementia with Lewy bodies (DLB) share clinical and molecular features. Cerebrospinal fluid (CSF) biomarkers may help the characterization of these diseases, improving the differential diagnosis. We evaluated the diagnostic performance of five CSF biomarkers across a well-characterized cohort of patients diagnosed with AD, ...
Nieuwe diagnostische criteria voor de ziekte van Alzheimer Vrije Universiteit Brussel
Gedragssyndromen bij milde cognitieve tekorten en bij de ziekte van Alzheimer Vrije Universiteit Brussel
Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation Vrije Universiteit Brussel KU Leuven Ghent University University of Antwerp
OBJECTIVE: To generate a clinical and pathologic phenotype of patients carrying rare loss-of-function mutations in ABCA7, identified in a Belgian Alzheimer patient cohort and in an autosomal dominant family.
METHODS: We performed a retrospective review of available data records, medical records, results of CSF analyses and neuroimaging studies, and neuropathology data.
RESULTS: The mean onset age of the mutation carriers (n = 22) ...
Rare Variants in PLD3 Do Not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort Vrije Universiteit Brussel KU Leuven University of Antwerp
Rare variants in the phospholipase D3 gene (PLD3) were associated with increased risk for late-onset Alzheimer disease (LOAD). We identified a missense mutation in PLD3 in whole-genome sequence data of a patient with autopsy confirmed Alzheimer disease (AD) and onset age of 50 years. Subsequently, we sequenced PLD3 in a Belgian early-onset Alzheimer disease (EOAD) patient (N = 261) and control (N = 319) cohort, as well as in European EOAD ...
Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia Vrije Universiteit Brussel KU Leuven University of Antwerp
Meta-analysis of existing genome-wide association studies on Alzheimer's disease (AD) showed subgenome-wide association of an intronic variant in the sequestosome 1 (SQSTM1) gene with AD. We performed targeted resequencing of SQSTM1 in Flanders-Belgian AD patients selected to be enriched for a genetic background (n = 435) and geographically matched nonaffected individuals (n = 872) to investigate the role of both common and rare SQSTM1 ...