Aß, Tau and neuronal death in a novel humanized mouse model for Alzheimer Disease KU Leuven
The relationship between Amyloid ɴ(Aɴpeptide, Tau, and neuronal cell loss is a central problem in the study of Alzheimer’s disease (AD). However, cell culture or animal models do not reproduce well the cell death phenotype that is crucial to analyze this relation. As it remains unclear to what extent rodent or other species can fully reproduce the AD phenotype, such study is performed ideally in human cells. In the current project, we take ...