Role y-secretase heterogeneity in intracellular AB production, lysosomal toxicity, and pathogenesis: contribution of familial Alzheimer’s disease mutations in presenilins and late onset Alzheimer’s disease risk factors KU Leuven
Alzheimer’s disease (AD) is characterized by amyloid β (Aβ) plaques and tangles. These hallmarks appear relatively late in disease stirring the debate whether they are a consequence of earlier pathogenic processes. Herein intracellular Aβ accumulation precede their formation, and correlates better with synaptic dysfunction and cognitive decline. Our recent data suggest that the composition of Aβ yielding γ-secretase complexes plays a role in ...