Projects

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Biomarker based adaptive development in Alzheimer disease. KU Leuven

Kris Dierickx
Interfaculty Centre for Biomedial Ethics and Law

Today, more than 46 million people worldwide are living with dementia (Wimo et al., 2013). This number will almost double every 20 years, with an estimated 74 million in 2030 and 131 million in 2050. Dementia refers to the decline of neuropsychological function, affecting one or more cognitive domains including memory, judgement, language, behavior, etc., whereby Alzheimer’s Disease (AD) is the most common type of dementia (Dubroff et al., ...

Aß, Tau and neuronal death in a novel humanized mouse model for Alzheimer Disease KU Leuven

Bart De Strooper
Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven Center for Brain & Disease Research)

The relationship between Amyloid ɴ(Aɴpeptide, Tau, and neuronal cell loss is a central problem in the study of Alzheimer’s disease (AD). However, cell culture or animal models do not reproduce well the cell death phenotype that is crucial to analyze this relation. As it remains unclear to what extent rodent or other species can fully reproduce the AD phenotype, such study is performed ideally in human cells. In the current project, we take ...

Alzheimer Disease - gut connection KU Leuven

Johan Hofkens
Molecular Imaging and Photonics

Alzheimer’s disease (AD) is the leading cause of dementia in the Western world and to date no cure nor any preventive strategy are available for this neurodegenerative disorder. Bacterial 16S rRNA sequencing from fecal samples revealed a remarkable shift in the gut microbiota of conventionally-raised AD mice compared to healthy, wild-type mice. Based on these findings, we generated germ-free Alzheimer (GF-AD) mouse model and discovered a ...

Analysing the function of APP as Wnt signaling receptor and the relevance for the Alzheimer disease. KU Leuven

Joris de Wit, Bassem Hassan
Laboratory of Synapse Biology (VIB-KU Leuven Center for Brain & Disease Research), Department of Human Genetics

Alzheimer’s disease (AD) is the most common form of dementia among the elderly. Research in the
AD field has been mostly focused on the biology of the Ab peptide but increasing evidence is shifting
attention toward the physiological role of APP as key to understanding AD pathology. It is becoming
apparent that APP plays a central role in the mechanisms that guarantee the accuracy and the
robustness of brain wiring. ...

Biomarker based adaptive development in Alzheimer (BioAdaptAD). University of Antwerp

Sebastiaan Engelborghs
Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO), Neurochemistry and behaviour
The general objectives of this project are to develop a BACE inhibitor for disease modification in Alzheimer's disease and to explore the development in an earlier prodromal Alzheimer's disease population. From a drug development perspective, this will involve multiple adaptation steps and the intensive use of biomarkers.

Investigating microglia inflammasome activation and regulation in Alzheimer disease Ghent University

Geert van Loo
Department of Internal Medicine and Pediatrics, Department of Biomedical molecular biology

Microglial cells are the resident mononuclear phagocytes of the central nervous system (CNS) and
have a functional role in both immune defense and CNS maintenance. These cells may however
also acquire a detrimental pro-inflammatory phenotype that involves the formation of
inflammasomes - cytosolic multi-protein complexes responsible for the production of proinflammatory
cytokines - and the induction of pyroptosis, a lytic ...

Population-based next generation sequencing to elucidate the complex genetics of Alzheimer dementia. University of Antwerp

Kristel Sleegers
VIB CMN - Neurodegenerative Brain Diseases Group
Alzheimer dementia (AD) is a very common, incurable disease. Because of changing demographics, the prevalence of AD increases rapidly. Recently, nine novel genes were identified that contribute to the risk to develop AD, and due to large scale international collaborations, several more are in the pipeline. This PhD project aims to identify the genetic polymorphisms in these genes that cause the increase in AD risk. To this end, next generation ...

Molecular epidemiological approaches in a translational study of complex Alzheimer dementia. University of Antwerp

Christine Van Broeckhoven
VIB CMN - Neurodegenerative Brain Diseases Group
Alzheimer dementia (AD) is a common, incurable disorder. Because of changing demographics, the prevalence of AD increases rapidly. This project aims to advance understanding of the genetic etiology of AD, amongst others in explorative association studies of genes in their biological networks, and ultra-high throughput sequencing to characterize allelic heterogeneity. In addition to AD we will also study the phenotype mild cognitive impairment to ...

Molecular correlation between Alzheimer disease and Fragile X syndrome. KU Leuven

Claudia Bagni
Department of Human Genetics, Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven Center for Brain & Disease Research)
Proper synaptic contacts, trans-synaptic signalling, and structural remodelling are all essential aspects of synapse maturation, stabilization and function. In humans, abnormal spine density and/or shape are associated with many neurological disorders referred to as synaptopathies, indicating a link among spine morphogenesis, synaptic function and disease. The Fragile X Syndrome (FXS) is a well-characterized synaptopathy and it is the most ...