Today, more than 46 million people worldwide are living with dementia (Wimo et al., 2013). This number will almost double every 20 years, with an estimated 74 million in 2030 and 131 million in 2050. Dementia refers to the decline of neuropsychological function, affecting one or more cognitive domains including memory, judgement, language, behavior, etc., whereby Alzheimer’s Disease (AD) is the most common type of dementia (Dubroff et al., ...
The relationship between Amyloid ɴ(Aɴpeptide, Tau, and neuronal cell loss is a central problem in the study of Alzheimer’s disease (AD). However, cell culture or animal models do not reproduce well the cell death phenotype that is crucial to analyze this relation. As it remains unclear to what extent rodent or other species can fully reproduce the AD phenotype, such study is performed ideally in human cells. In the current project, we take ...
Alzheimer Disease - gut connection KU Leuven
Alzheimer’s disease (AD) is the leading cause of dementia in the Western world and to date no cure nor any preventive strategy are available for this neurodegenerative disorder. Bacterial 16S rRNA sequencing from fecal samples revealed a remarkable shift in the gut microbiota of conventionally-raised AD mice compared to healthy, wild-type mice. Based on these findings, we generated germ-free Alzheimer (GF-AD) mouse model and discovered a ...
Analysing the function of APP as Wnt signaling receptor and the relevance for the Alzheimer disease. KU Leuven
Alzheimer’s disease (AD) is the most common form of dementia among the elderly. Research in the
AD field has been mostly focused on the biology of the Ab peptide but increasing evidence is shifting
attention toward the physiological role of APP as key to understanding AD pathology. It is becoming
apparent that APP plays a central role in the mechanisms that guarantee the accuracy and the
robustness of brain wiring. ...
Biomarker based adaptive development in Alzheimer (BioAdaptAD). University of Antwerp
Investigating microglia inflammasome activation and regulation in Alzheimer disease Ghent University
Microglial cells are the resident mononuclear phagocytes of the central nervous system (CNS) and
have a functional role in both immune defense and CNS maintenance. These cells may however
also acquire a detrimental pro-inflammatory phenotype that involves the formation of
inflammasomes - cytosolic multi-protein complexes responsible for the production of proinflammatory
cytokines - and the induction of pyroptosis, a lytic ...