Human-mouse neuronal xenografts to study incipient Alzheimer’s Disease. KU Leuven
Alzheimer’s disease is a major health problem. Progress in the field has been hampered seriously by the lack of a good animal model to study the early steps of the disease. We have developed a new xenograft mouse model for Alzheimer's disease. We transplant human neuronal precursor cells in mouse brain. Remarkably these neurons integrate well and survive >18 months. However when we transplant the neurons in a mouse model that develops the ...