Projects
The impact of advanced age and age-related diseases on drug absorption KU Leuven
The absorption of drugs from oral dosage forms is largely controlled by drug dissolution in the gastrointestinal contents and drug permeation through the intestinal epithelium. However, the influence of age and age-related diseases on these processes is poorly understood. The overall goal of this project is to generate information on drug and formulation behaviour in older people and geriatric patients, and on physiological characteristics of ...
Immune profiling of Chronic inflammatory demyelinating polyradiculoneuropathy. KU Leuven
Chronic inflammatory demyelinating polyneurorpathy (CIDP) is a
neurological disorder in which inflammation results in muscle
weakness and sensory deficits. CIDP is a very heterogeneous
disease as some people have both muscle and sensory complaints,
where others only have muscle or sensory complaints. Also in some
the disease starts gradually where in others it starts in an acute way.
Current techniques do not ...
Investigation of G-protein coupled receptors conformational dynamics via single-molecule fluorescence microscopy. Hasselt University
COMPREHENSIVE AUTOMATED MONITORING OF DIETARY INTAKE USING AN INTELLIGENT SYSTEM KU Leuven
Healthy dietary intake is essential for living a high quality lifestyle and has the potential to directly prevent eating-related diseases affecting millions of people worldwide. What and how much we eat and drink has an important impact on our health. Diet-related diseases are a major public health concern and continue to endanger our population’s health and the sustainability of our healthcare systems. Unbalanced dietary intake (relating to ...
Atomic Force Microscopy Enhanced Spectroscopy to Study Strains and Seeding of Amyloids In Situ KU Leuven
The establishment of the Molecular Biophysics Leuven core facility at the Gasthuisberg campus has made biophysical approaches more accessible to the biomedical research community and has yielded many fruitful collaborations amongst the members of this interest group. In this grant, we are aiming to extend the instrument park of this facility with an atomic force microscope (AFM) coupled with a Raman spectroscope and an epifluorescent ...
Automated sleep analysis from wearable monitoring devices. KU Leuven
Sleep-wake disturbances are widespread across the disease spectrum. They are among the earliest and most disruptive symptoms in Alzheimer’s disease (AD), which is the number one neurodegenerative disease and represents a huge burden in our aging society. Sleep-wake disturbances are also associated with epilepsy, which in turn interacts with AD. While there is plenty of evidence for the interplay between AD, epilepsy and sleep, the nature of ...
Computational analysis on the effect of post-translational modifications on amyloid interactions KU Leuven
Protein aggregation is a common pathological hallmark of a large number of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, as well as many metabolic diseases and cancer. This phenomenon results from the self-assembly of short regions of mainly hydrophobic amino acids (APRs) into stacked structured sheets called steric zippers. Mounting evidence suggest that protein post-translational modifications (PTMs) can often increase or ...
Click chemistry Options for Live Immuno Brain Imaging KU Leuven
As the world’s population is living longer, age-related neurodegenerative diseases (ND) such as Alzheimer’s and Parkinson’s are becoming a larger global issue. To date, no cure exists, and the European Union considers the understanding and the diagnosis of ND as key research areas. In this context, the overall aim of the fellowship is the development of a versatile method for immuno based brain PET, as a general translational molecular ...
Precision genomics in neurodegenerative brain disease: from patients to small model organisms and single cells Ghent University
We will study genomic aspects of rare neurodegenerative brain disorders (NBD). First, we will establish a multidisciplinary clinical neurogenetics program at UZ Gent. Second, we will use fruit flies to study the potential pathogenic nature of novel NBD-related genetic variants. Third, we will use single-cell sequencing to study the role of genomic mosaicism in neurodegeneration.