Pyroptotic cell death in Alzheimer’s disease: pathological relevance and functional in vitro analysis. KU Leuven
Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder, resulting in memory loss and cognitive dysfunction. The major neuropathological hallmarks of AD are accumulations of amyloid β (Aβ) and hyperphosphorylated Tau protein (pTau), accompanied by neuron loss and neuroinflammation. The mechanisms leading to neuronal death in AD and the contribution of glial cells in these processes are still not sufficiently understood. ...