Projects
Tau-based Mabs and Vaccines: development and pre-clinical assessment of diagnostic and therapeutic potential in transgenic models for Tauopathy & Alzheimer's disease. KU Leuven
Resilience and vulnerability in the cellular phase of Alzheimer’s disease. KU Leuven
This project proposes an integrative approach to assess how the different pathological mechanisms of AD are linked to each other and how genetic risk of AD underlays resilience or vulnerability. While the classical neuron-centric view on AD pathogenesis sees amyloid peptides as triggers of synaptic dysfunction and Tau pathology as the executor of neurodegeneration, it is now clear that other cell types also react to amyloid plaques and that ...
Herpesvirus-induced neuroinflammation in the peripheral nervous system (PNS) as a ‘distant’ trigger of Alzheimer’s disease Ghent University
Alzheimer’s disease (AD) is a neurodegenerative disorder affecting 26 million people worldwide. To date, there is no cure and current therapies are not effective in delaying progression. Thus, there is an urgent need to change the way of looking at the disease and to rethink possible therapies. Herpes simplex virus type 1 (HSV1) has recently received growing attention for its role in AD. HSV1 infects the mouth and invades peripheral sensory ...