Ulcerative colitis (UC) is a debilitating intestinal inflammatory disorder affecting approximately 1:200 people, the prevalence of which is disproportionately high in Europe. As well as experiencing severe clinical symptoms, 10-18% of UC patients develop inflammation-associated colon cancer. The molecular mechanisms underpinning both the pathology and increased risk of cancer in UC patients remain unclear and effective treatment is a clearly ...
Identifying molecular mechanisms underlying the effects of ethanol on eukaryotic genome instability KU Leuven
Around 6% of all cancers worldwide are associated with alcohol consumption. For example, the risk of developing head and neck tumors greatly increases with increasing alcohol consumption. Although alcohol consumption is estimated to be the cause of 800.000 cancer cases worldwide, the exact mechanism by which alcohol affects tumorigenesis is not fully understood yet. This also implies that very little is known about the molecular mechanisms ...
Human pituitary tumorigenesis: disease modeling using 'induced pluripotent cancer' (iPC) cells as innovative approach towards mechanistic insight and therapeutic target identification. KU Leuven
The pituitary gland takes, together with the hypothalamus, the main lead in coordinating the endocrine system to regulate vital physiological body processes like growth, puberty, reproduction and stress response. Because of this central role, malfunctioning of the pituitary can cause severe disorders like diabetes, cardiovascular disease, osteoporosis, infertility and psychological problems. Pituitary hormonal cell populations must therefore ...
Evaluation of the role of the proprotein convertase furin in liver: involvement in non-alcoholic steatohepatitis and hepatocellular carcinoma. KU Leuven
MERKEL CELL CARCINOMA, TOWARDS THE IDENTIFICATION OF NOVEL MOLECULAR TARGETS AND THE ESTABLISHMENT OF A THREE-DIMENSIONAL CELL CULTURE MODEL KU Leuven
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma. Nevertheless, its incidence has increased in the last few years and this trend is predicted to persist. Furthermore, with a general mortality rate of 33-46% and a high rate of recurrences, it is one of the most aggressive types of skin cancer. Currently, MCC has two recognized etiologies. Merkel cell polyomavirus (MCPyV) DNA is found clonally integrated in the genome of ...
Protein aggregation in cancer development: novel heat shock inducing compounds to reduce tumor growth. KU Leuven
Targeting protein aggregation during cancer development
1.1 Mutant p53 protein can exert gain-of-function activity by protein aggregation
Cancer remains one of the leading causes of morbidity and mortality worldwide, and understanding the underlying molecular mechanisms of the disease still forms a major challenge1-4. The p53 tumor suppressor protein, a master regulator of cell cycle arrest and apoptosis, is a cardinal player in ...
The marginal zone B cel in concordant xenograft rejection: critical help signals in the T cel-independent type II xenoantibody response and possible targets for xeno-immunosuppression. KU Leuven
Allogeneic hematopoietic stem cell transplantation
(HSCT) and posttransplant adoptive cell therapy with donor leukocyte infusions
(DLI) are known to exert potent graft-versus-leukemiaeffects and convincing
evidence is emerging that this approach can also elicit responses against solid
tumors. Graft-versus-leukemia effects specifically after DLI largely rely