Projects
Integrated material science, enginomic and kinetic approach to understand aging, processing and digestion of legumes -“Engaging Legumes” KU Leuven
Radiation Hardened Aging Resilient Digital Integrated Circuits in Nanoscale CMOS Technology KU Leuven
long-term reliability of recent CMOS technologies is impacted by different intrinsic degradation mechanisms that progressively alter their electrical characteristics (BTI, HCI, TDDB...). Due to the ongoing aggressive scaling process, those mechanisms exhibit significant dispersions related to the process details and variability. The parametric evolution induced by those mechanisms constitutes a reliability risk, both directly, by compromising ...
Molecular neurobiology of aging. KU Leuven
Aging is the primary risk factor for many human pathologies such as cardiovascular diseases, cancer, diabetes and neurodegenerative disorders. Therefore, societal aging comes with an emotional and financial burden of age−related health issues and diseases, most of which go without a cure. While vast amounts of money are being spent on the study of aging−related diseases, surprisingly little investments have been made to sort out the ...
Neuroendocine modulation of healthy aging. KU Leuven
Aging and movement control: towards a multimodal imaging approach for the study of brain structure, function, and connectivity KU Leuven
The impact of reproductive axis hormones on changes in brain functional networks during healthy, accelerated and pathological aging (i.e. Alzheimer's disease). University of Antwerp
DNA methylation in cardiac aging and disease and its potential interaction with Ca2+ handling pathways. KU Leuven
Cardiovascular diseases, including heart failure and atrial fibrillation are the leading cause of mortality worldwide. With age the greatest risk factor, their prevalence will substantially increase in the next decades. Factors contributing to this age-associated susceptibility to development of pathology are not established making the identification of new mechanistic targets and prognostic indicators of cardiac health urgently required. ...
The pathomechanism of spontaneous peripheral neuropathy in aging rats Ghent University
In ageing rats, there is a high incidence of spontaneous peripheral neuropathy, resulting in hind limb paresis, evolving to complete hind limb
paralysis. Lesions developing in the rats’ peripheral nervous system will be followed up
in vivo, using Diffusion Tensor Imaging (DTI) and electrophysiological examination. Thereafter, early pathobiology of the disorder will be studied more in depth.