Listening with age: disentangling peripheral and cortical processing in the aging auditory system. KU Leuven
The impact of reproductive axis hormones on changes in brain functional networks during healthy, accelerated and pathological aging (i.e. Alzheimer's disease). University of Antwerp
IL-13-overexpressing anti-inflammatory macrophages suppress trauma induced premature immune aging. Hasselt University
Aging and movement control: towards a multimodal imaging approach for the study of brain structure, function, and connectivity KU Leuven
Fidelity of translation in healthy aging KU Leuven
I will study the molecular mechanisms underlying longevity and healthy aging in Caenorhabditis elegans, which could contribute to solutions of the aging human population. Specifically, I will decipher the role of ribosomal subunits in translation fidelity and healthy aging, test longevity-extending compounds, and confirm my C. elegans results in human cell lines.
Aging and brain plasticity: alterations in brain structure, function and connectivity in relation to complex motor behavior. KU Leuven
Study of the aging process: the role of N-glycosylation, hormones and the Klotho gene. Ghent University
N-glycosylation is altered during aging and specific glyco-genes are responsible for this process. We will analyze the regulation of involved glyco-genes by in silico analysis and functional promoter studies. Next, we will study the influence of alterations of the N-glycosylation pattern on the aging process itself as well as on aging-related signaling pathways. This will be done both in vitro and in vivo.