Mitochondrial DNA content in cardiovascular ageing and disease: a population study. KU Leuven
A major burden of modern society is the progressive increase in age-associated diseases such as heart failure (HF). The genetic and environmental drivers of left ventricular (LV) dysfunction progression remain to be elucidated. LV dysfunction is associated with changes in cardiac energy metabolism. Mitochondria play a central role in a variety of cardiac cell functions. The mitochondrial DNA (mtDNA) content correlates with the size and number ...