Publications
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Nodding syndrome and epilepsy in onchocerciasis endemic regions Institute of Tropical Medicine University of Antwerp
BACKGROUND: Nodding syndrome (NS) is an epilepsy disorder occurring in children in South Sudan, northern Uganda and Tanzania. The etiology of NS is unknown, but epidemiological studies demonstrate an association between NS and onchocerciasis. METHODS: Between November 2013 and July 2015 we visited onchocerciasis endemic regions in South Sudan, Uganda, and the Democratic Republic of the Congo (DRC) to assess the epilepsy situation. In South Sudan ...
Filovirus epidemic in 1956 in Bili, DRC [letter] Institute of Tropical Medicine
Achievements and lessons learnt from facility-based maternal death reviews in Cameroon Institute of Tropical Medicine
Paediatric pharmacovigilance Institute of Tropical Medicine
TLTF in cerebrospinal fluid for detection and staging of T. b. gambiense infection Institute of Tropical Medicine
BACKGROUND: Trypanosome-derived lymphocyte triggering factor (TLTF) is a molecule released by African trypanosomes that interacts with the host immune system, resulting in increased levels of IFN-gamma production. METHODOLOGY/PRINCIPAL FINDINGS: TLTF and anti-TLTF antibodies were assessed in sera and cerebrospinal fluid (CSF) from patients infected with Trypanosoma brucei gambiense (T. b. gambiense) in an attempt to identify alternative markers ...
Neopterin is a cerebrospinal fluid marker for treatment outcome evaluation in patients affected by Trypanosoma brucei gambiense sleeping sickness Institute of Tropical Medicine
BACKGROUND: Post-therapeutic follow-up is essential to confirm cure and to detect early treatment failures in patients affected by sleeping sickness (HAT). Current methods, based on finding of parasites in blood and cerebrospinal fluid (CSF) and counting of white blood cells (WBC) in CSF, are imperfect. New markers for treatment outcome evaluation are needed. We hypothesized that alternative CSF markers, able to diagnose the meningo-encephalitic ...
Stage determination in sleeping sickness: comparison of two cell counting and two parasite detection techniques Institute of Tropical Medicine
OBJECTIVES: Diagnosis of the neurological stage of human African trypanosomiasis is performed by examination of cerebrospinal fluid (CSF) for the presence of trypanosomes and numbers of white blood cells (WBC). Both CSF parameters are also used to assess treatment outcome during follow-up. In view of the importance of CSF examination, and the practical problems encountered with it, we compared the sensitivity of two trypanosome concentration ...
Effects of pyrethroid resistance on the cost effectiveness of a mass distribution of long-lasting insecticidal nets: a modelling study Institute of Tropical Medicine
BACKGROUND: The effectiveness of insecticide-treated nets in preventing malaria is threatened by developing resistance against pyrethroids. Little is known about how strongly this affects the effectiveness of vector control programmes. METHODS: Data from experimental hut studies on the effects of long-lasting, insecticidal nets (LLINs) on nine anopheline mosquito populations, with varying levels of mortality in World Health Organization ...
Birds of a feather: homophily and sexual network structure in sub-Saharan Africa Institute of Tropical Medicine
Sexual partner homophily is the tendency of individuals to choose partners similar to themselves. The extent and nature of partner homophily influences the structure of sexual networks and hence the spread of sexually transmitted infections (STIs). In this paper, we compare homophily by ethnicity, age and educational status in representative populations from five African cities in Benin (Cotonou), Cameroon (Yaounde), Kenya (Kisumu), Zambia ...