Projects
Antibacterial dose optimisation based on augmented renal clearance in adult critically ill patients and selected pediatric patients KU Leuven
Cardiorespiratory fitness, physical activity and long term health in adult patients with congenital heart disease. KU Leuven
Outcome of JIA patients on biologicals after transition to adult rheumatology KU Leuven
Background:
About 40-60% of JIA patients still have active disease when they reach adulthood, meaning that preventing the adult consequences of a childhood-onset disease is a new challenge for caregivers. We have to understand the long-term morbidity and mortality of childhood-onset rheumatic diseases to make an improvement in their outcomes in adulthood. Additionally, different retrospective or cross-sectional studies showed Juvenile ...
Evaluation of the molecular determinants of primary immunodeficiency in adult patients, pathogenesis of STAT1 gain-of-function and evaluation of gene therapeutic approaches. KU Leuven
Primary immunodeficiencies (PIDs) have provided crucial information for the elucidation of immunological pathways. Although many causal mutations in PID patients have been identified, the exact pathogenesis often remains to be elucidated and clues for an individualized therapeutic approach remain absent. In this project we focus on adult patients with a confirmed or suspected primary immunodeficiency. We explore a genetic cause in patients ...
An image-based personalized musculoskeletal modeling and simulation framework for functional analysis of activities of daily living in adult spinal deformity patients KU Leuven
Adult spinal deformity (ASD) is a complex disorder of the spinal column that results in a wide range of three-dimensional (3D) spinal deformities, often leading to a severe disability during activities of daily life for those affected by it. Surgical treatments aiming to realign the spine within normative values by fusing together individual vertebrae with rods and screws have been increasingly used to treat ASD. These surgeries are currently ...
Decubitus prevention in adult intensive care patients HOGENT
Next-generation immune biomarkers to improve clinical immunotherapy options for pediatric and adult patients with glioblastoma: a multi-omics, translational immunology and artificial intelligence-driven approach KU Leuven
The aim of this project is to present a clinically useful research protocol at the end of the 4 years that will use scientifically validated biomarkers to identify the most appropriate (combinations of) immunotherapies in a personalized way for every brain tumor patient, pediatric and adult. to select a clinical trial. To achieve this biomarker-based selection, combinations of the most advanced molecular cell biological research methods and ...