Projects
Stem Cell and Stromal Vascular Fraction Treatment for Penile Tunica Albuginea and Urethral Fibrosis KU Leuven
Fibrosis is a wound healing disorder and it is defined by the excessive accumulation of fibrous connective tissue, such as collagen and fibronectin, in and around inflamed or damaged tissue. Although collagen and fibronectin deposition is an indispensable and, typically, reversible part of wound healing, normal tissue repair can evolve into a progressively irreversible fibrotic response if the tissue injury is severe or repetitive or if the ...
Cultured myoblasts and mesenchymal stem cells for customized meat design KU Leuven
This work aims to address several challenges that exist in the field of cultured meat research. In order to produce meat from cell culture efficiently, cells must possess extensive proliferative and differentiation capacity. This poses a question: which cell type suits this cause the most? Two adult progenitor cells will be compared: myoblasts and adipose tissue derived mesenchymal stem cells. Upon evaluation, a chosen cell type will be ...
ADIPINJECT: Development for injectable temperature-responsive hydrogels for adipose tissue engineering Ghent University
Injectable solutions for adipose tissue engineering have recently gained increasing attention among others by lipofilling procedures, breast constructions, wound treatment, ... With the aim to meet an urgenet need in the medical field, the present project aims at developing biomimetic, injectable temperature-responsive hydrogel building blocks suitable for adipose tissue regeneration. Biocompatible hydrogel building will be developed and be ...
Perianal fistulas in Crohn’s disease: new insights on pathogenesis, diagnosis and treatment. KU Leuven
Introduction Perianal fistulizing Crohn’s disease (pCD) develops in 20% and recurs in 30% of Crohn’s disease (CD) patients and typically follows a relapsing and remitting course. (1) The natural course of the disease is highly unpredictable. Most data are derived from outdated population-based studies and historical series. (2-5) After a mean duration of 10 years, 51% of patients with pCD are in stable remission, 9% have persistent drainage ...
The role of CD36 and COUP-TFII in adipogenesis and adipose tissue related angiogenesis. KU Leuven
Regucyte : Bringing Regenerative Medicine to the Clinic Ghent University
Adipose tissue and its byproducts are often used in the operating room (OR). Adipose tissue is transplanted in the same patient to treat surgical defects. Byproducts such as stromal vascular fraction (SVF) are used in regenerative medicine. When working with adipose tissue, an ischemia time of less than 6h is respected. Afterwards adipose tissue and its byproducts suffer cell death. We discovered a new technology to prolong the survival of ...
Skeletal control of hematopoiesis: Impact of the stromal-vascular bone marrow niche in the support of fetal and adult hematopoiesis KU Leuven
Bone is not only crucial for allowing movement, providing support and protection for vital organs and maintaining mineral homeostasis, but the skeleton also represents the prime site for blood cell production or hematopoiesis. To ensure constant blood cell levels under homeostatic conditions and rapid responses to emergencies or injuries, the balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) needs to be ...
Role of CD36 in adipogenesis and adipose tissue development. KU Leuven
New avenues in the management of pelvic floor disorders: experimental secondary prevention and medium term outcomes of abdominal mesh surgery KU Leuven
Pelvic floor disorders (PFD) include pelvic organ prolapse (POP), urinary (UI) & fecal incontinence (FI), sexual dysfunction and pelvic pain. Twelve years after first vaginal delivery around 23% of women leak urine at least once a week, and around 24% of women have stage 2+ POP1 The prevalence of FI in women increases with age, from 6% in women < 40 years rising to 15% in older women. Up to 50% of the patients with FI also report UI.2 ...