Publications
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The efficacy and safety of zidovudine alone or as cotherapy with acyclovir for the treatment of patients with AIDS and AIDS-related complex; a double-blind, randomized trial Institute of Tropical Medicine
The efficacy and safety of zidovudine with or without acyclovir in the treatment of patients with AIDS-related complex Institute of Tropical Medicine
Topical use of 5% acyclovir cream for the treatment of occult and verrucous equine sarcoids : a double-blinded placebo-controlled study Ghent University
Topical distribution of acyclovir in normal equine skin and equine sarcoids : an in vitro study Ghent University
Pharmacokinetics and clinical efficacy of acyclovir in the treatment of equine herpes virus type 1 infections Ghent University
Is acyclovir effective among critically ill patients with herpes simplex in the respiratory tract? University of Antwerp
Background and objective: The relevance of the detection of herpes simplex virus type 1 (HSV-1) in the respiratory tract of patients in the intensive care unit (ICU) is unclear. Therefore, it is uncertain whether treatment with an antiviral agent could be beneficial for these patients. Study design: We retrospectively reviewed the records of ICU patients with a positive HSV-1 culture in the respiratory tract or bronchoalveolar lavage (BAL) ...
Acyclovir resistance in herpes simplex viruses: Prevalence and therapeutic alternatives KU Leuven
Herpes simplex viruses (HSV), the causative agents of recurrent orofacial and anogenital infections, can cause significant morbidity and mortality in both immunocompetent and immunocompromised individuals. In immunocompromised patients, HSV tends to be more persistent with chance of dissemination. The nucleoside analogue acyclovir has drastically improved the management of HSV infections although acyclovir resistant strains have been reported in ...
A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2 KU Leuven
BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 2 (HSV-2) are responsible for 2 intersecting epidemics in which the disease caused by 1 virus facilitates the transmission of and pathogenesis by the other. Therefore, suppression of one virus infection will affect the other. Acyclovir, a common antiherpetic drug, was shown to directly suppress both viruses in coinfected tissues. However, both antiviral ...