Projects
Geographic transferability of Activity-Based models: A Flanders-Slovenia case study Hasselt University
The synthesis and application of novel activity-based probes for the visualization of cysteine proteases. KU Leuven
Proteases are enzymes that cut proteins by catalyzing the hydrolysis of the peptide bond. They can be found in almost every organism, where they play a part in many biological pathways and are involved in various human diseases. For example, cathepsins, a class of cysteine proteases, are upregulated in various cancers, making them an interesting biomarker and suitable targets for tumor labeling.
An excellent method for the detection of ...
Design, Synthesis and Biochemical evaluation of novel serine protease activity-based probes. University of Antwerp
Changed activity and travel behaviour of people with Multiple Sclerosis: identification of factors based on dynamic activity-based transportation models, while taking into account personal limitations Hasselt University
Development of a caspase-3 selective activity-based probe for PET imaging of apoptosis University of Antwerp
Integrating Urban Model And Activity-Based Travel Demand Model Hasselt University
Activity-based probes for PET imaging of protease activity. University of Antwerp
Development of photo-activatable protease inhibitors and activity-based probes and their application in the study of dynamic proteolytic processes KU Leuven
Proteases are involved in many highly regulated biological processes, such as apoptosis, cell-cell communication and blood coagulation. Inhibitors and activity-based probes (ABPs) have been successfully utilized as chemical tools to study these enzymes. However, when studying fast and dynamic processes, local and temporal acivation of these reagents is desirable. Such reagents can first of all be used for basic study of these processes, but ...