Validation of autophagy induction as a therapeutic strategy: from drug discovery and preclinical evaluation to safety investigation and biomarker research. University of Antwerp
Molecular Imaging and Radiology (MIRA), Toxicological Centre, Physiopharmacology (PHYSPHAR), Peripheral Neuropathies Group, Medicinal Chemistry (UAMC)
Autophagy is a ubiquitous process that removes unnecessary or dysfunctional cellular components from the cytoplasm. Defective autophagy is currently emerging as a hallmark of many diseases. In this framework, there is strong interest in pharmacological agents that stimulate autophagy (so-called 'autophagy inducers'), as a potential treatment for these diseases. The unequivocal validation of autophagy induction as a therapeutic strategy, however, ...