Synthesis and structure-activity relationship studies of CCR8 agonists as a novel treatment option for autoimmune diseases KU Leuven
Chemokines (chemoattractant cytokines) are a group of small (8 –10 kDa) and predominantly basic proteins that play an important role in the human immune system by regulating the migration and activation of immune cells. These chemokines are divided into three subfamilies based on the location of the first two cysteine (C) residues: CC-chemokines, CXC -chemokines, and CX3Cchemokines (with X being a variable amino acid). C-chemokines are ...