Projects
Development of the VersaTile technique and a microdroplet assay for the ultrahigh-throughput engineering of lysins as antibacterial agents KU Leuven
The discovery and development of antibiotics have shaped modern medicine. However, our health care system is increasingly threatened by antimicrobial resistance. Despite warnings since the very beginning, overuse and misuse of antibiotics have led to the emergence and spread of antimicrobial resistance against every known antibiotic. Moreover, many pharmaceutical companies have abandoned the search and development of new antibiotics due to ...
Development of a novel diagnotic assay for the biochemical diagnosis of mitochondrial disorders in vital tissue KU Leuven
Primary mitochondrial disorders are characterized by aberrancies in normal mitochondrial functioning due to mutations in either nuclear or mitochondrial DNA-encoded genes. The estimated prevalence is at least 1 in 5.000 births, suggesting that there are at least 1.200 individuals in Flanders with an inherited mitochondrial disorder. However, less than 250 patients in Flanders have a diagnosis. We follow approximately 100 patients with a ...
Validating the application of a first-in-class human serum-functional immunodynamic status (sFIS) assay as bona fide immuno-oncology biomarker KU Leuven
Identification of pan-cancer and tumor-specific methylation based biomarkers and development of bioinformatics infrastructure for a novel multiplex methylation assay. University of Antwerp
Development of an alternative testing strategy for the fish early-life stage test for predicting chronic toxicity : assay validation. University of Antwerp
Development and validation of a peripheral blood mRNA assay for the assessment of antibody-mediated kidney allograft rejection: A multicentre, prospective study KU Leuven
New alternative carcinogenic prediction assay using flatworm stem cell proliferation patterns. Hasselt University
Pandemic preparedness: developing a multiplexed mass spectrometry assay to screen for pathogens and the induced immune response. Ghent University
The SARS-CoV-2 pandemic has abruptly illustrated the lack of pandemic preparedness. Therefore, health organisations as the WHO have recommended the development of a robust molecular screening platform for early detection and monitoring of the spread of pathogens through the population. This implies supplementing current diagnostic tests like nucleic acid amplification tests (NAATs) with tests targeting other biomolecules, like proteins. ...