Projects
Structure-based drug design targeting Nipah virus RNA polymerase KU Leuven
Nipah virus is a zoonotic disease pathogen believed to originate from Fruit bats. Based on different outbreaks, the data from WHO estimated the human case fatality rate at 40% to 75%. The Nipah virus is one of the pathogens in the WHO R&D Blueprint list of epidemic threats based on its urgent for effective tests, vaccines, and medicines. Antivirus drugs have a long shelf life and a lower demand for cold chain transportation than vaccines ...
Functional reconstitution of Type 3 protein targeting and secretion KU Leuven
‘Bisceps’ Biofilm susceptibility sensors for in situ biofilm monitoring. KU Leuven
Biofilms are-surface associated microbial communities that are highly tolerant against antimicrobials and therefore cause persistent contaminations and infections in industrial and medical sectors. In particular, biofilms formed on medical implants often lead to chronic infection and implant replacement, whereas biofilms in food and other industries can lead to product contamination. This project aims at the development of a novel sensor ...
Probing the evolutionary robustness of antimicrobial combination therapy to combat biofilm-related infections caused by Gram-negative bacteria Ghent University
that increase the effect of antibiotics and/or the use of anti-virulence drugs are considered as possible innovative approaches to combat difficult to threat biofilm-related infections. In this doctoral work I will investigate if and how resistance towards this kind of treatment develops, using an experimental evolution approach.
Live cell imaging of phosphatidylserine-annexin A5-mediated pinocytosis: study of targeted drug delivery for cervical cancer University of Antwerp
Study of cellular factors involved in Respiratory Syncytial Virus (RSV) infection KU Leuven
This doctoral project focuses on the study of (new) cellular factors that contribute to the entry and replication of the human Respiratory Syncytial Virus (RSV). Using in vitro genetic screenings, we aim to identify and characterize cellular proteins (receptors, proteases, …) which are necessary for an efficient RSV infection in cell cultures. In addition, we will investigate the antiviral activity of novel anti-RSV compounds.