BOF-ZAP-office in Blue biotechnology and antivirulence therapy Ghent University
BOF-ZAP-office in Blue biotechnology and antivirulence therapy (Tom Defoirdt)
BOF-ZAP-office in Blue biotechnology and antivirulence therapy (Tom Defoirdt)
Antivirulence therapy is a promising novel method to control (antibiotic resistant) infections. In this respect, interfering with quorum sensing, bacterial cell-to-cell communication, is the most intensively investigated strategy. There still is debate with respect to the risk of resistance
development against such a strategy. In this project, we will evaluate this risk in a host-pathogen model system.
that increase the effect of antibiotics and/or the use of anti-virulence drugs are considered as possible innovative approaches to combat difficult to threat biofilm-related infections. In this doctoral work I will investigate if and how resistance towards this kind of treatment develops, using an experimental evolution approach.