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A realist evaluation of the antiretroviral treatment adherence club programme in selected primary health care facilities in the metropolitan area of the Western Cape Province, South Africa Institute of Tropical Medicine

Brian van Wyk, Bruno Marchal
Health Policy, Complexity and Health
Background: Retention in care and treatment adherence are key challenges to national antiretroviral therapy (ART) programmes in Sub-Saharan Africa. Innovative community-based approaches to HIV care and treatment have been proposed and implemented in several Sub- Saharan African countries to improve retention in care and adherence rates of patients on ART. One of such innovations, the „ART adherence club‟ was developed and piloted in the Western ...

Modeling CD4 count of HIV/AIDS patients' before and after the initiation of Antiretroviral therapy (ART) in Amhara Region, Northwest Ethiopia. Hasselt University

Ziv SHKEDY
Centre for Statistics
Introducing antiretroviral therapy (ART) has averted 2.5 million deaths in low- and middle-income countries globally since 1995. Sub-Saharan Africa accounts for the vast majority of the averted deaths: about 1.8 million. More than 8 million people had access to antiretroviral therapy in 2011 in low and middle-income countries which indicate 20% increase from 2010. In Ethiopia the cumulative number of patients who have ever started treatment ...

Antiretroviral treatment as catalyst for achieving AIDS competence in local South African communities: developing a multidimensional intervention to combat the HIV/AIDS epidemic. University of Antwerp

Edwin Wouters
Centre for Population, Family and Health
Background: Although the initial outcomes of the South African public antiretroviral treatment (ART) programme are promising, there are still important challenges to be met to successfully fight the HIV/AIDS epidemic in the long term, namely (1) HIV/AIDS care as chronic disease care requires psychosocial care on top of biomedical care to ensure long-term adherence and patient retention and (2) HIV incidence levels need to drop by positively ...

HIV Illness Identity, Household HIV Competence and Antiretroviral Treatment Adherence, an analysis of associations among a treatment-naïve adult population living with HIV in the Western Cape, South Africa. University of Antwerp

Edwin Wouters
Centre for Population, Family and Health
The HIV/AIDS epidemic is still severely impacting South Africa: in 2021, approximately 1 out of 5 adult South Africans was HIV positive. As a response, the South African government has rolled out life-saving antiretroviral treatment (ART) in the public health sector, with approximately 5.5 million people currently receiving ART. ART has been proven to be highly effective: when achieving 95% adherence, HIV is transitioned from a terminal illness ...

Immunopathogenesis of the immune reconstitution inflammatory syndrome (IRIS) in TB/HIV patients commencing antiretroviral therapy: search for prognostic and diagnostic markers. University of Antwerp

Luc Kestens
Department of Biomedical Sciences - other, Laboratory for Microbiology, Parasitology and Hygiene (LMPH)
This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.

Immunopathogenesis of the immune reconstitution inflammatory syndrome (IRIS) in TB/HIV patients commencing antiretroviral therapy: search for prognostic and diagnostic markers. University of Antwerp

Luc Kestens
Department of Biomedical Sciences - other, Laboratory for Microbiology, Parasitology and Hygiene (LMPH)
This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.

The hybrid identity of the HIV/AIDS patient: a qualitative study of the impact of antiretroviral treatment on the lives of HIV/AIDS patients in South Africa University of Antwerp

Edwin Wouters
Centre for Population, Family and Health
Antiretroviral treatment has transformed AIDS from an acute, degenerative disease into a chronic - albeit incurable - illness. Hence, the illness is not an external assault on the body, but an internal one, becoming part of the patient's identity as a 'chronic HIV/AIDS patient'. This research project aims to assess the mechanisms through which the illness and the associated treatment influence the lives and the identity of the patients.

The hybrid identity of the HIV/AIDS-patient: a longitudinal study of the impact of antiretroviral treatment on the life of HIV/AIDS-patients in sub-Saharan Africa. University of Antwerp

Herman Meulemans
Centre for Sociology of Law, Centre for Population, Family and Health
The general research aim is to undertake a sociological study of the impact of HIV/AIDS and the associated ART on the lives of those affected and more specifically on the identity reconstruction of HIV/AIDS patients receiving ART in sub-Saharan Africa. This research views ART not only as the turning point in the treatment of an 'ill body', detached from the social reality, but also as a turning point in the experience of AIDS as a chronic ...

HIV-1 integration as a driver of clonal expansion and HIV-1 transcription during antiretroviral therapy Ghent University

Linos Vandekerckhove
Department of Internal Medicine and Pediatrics

HIV-1 infection remains an incurable disease, with the latent virus persisting in the immune cells invisible to therapy and causing viral rebound within days once therapy is stopped Recent new insights show that cells that harbor HIV can divide, by a process called clonal expansion Clonal expansion of cells carrying HIV-1 is considered as being part of the main mechanisms of HIV-1 persistence, with our own data confirming its importance in ...

Key performance indicators for improving the last mile in antiretroviral therapy to prevent HIV drug resistance in Tanzania. KU Leuven

Nico Vandaele
Faculty of Business and Economics, Kulak Kortrijk Campus, Laboratory of Clinical and Epidemiological Virology (Rega Institute)

This transdisciplinary, human-centered project proposal will generate key performance indicators that have to be met in order to prevent HIV drug (HIVDR) resistance in Dar es Salaam, Tanzania. In an existing VLIR-SI, the factors driving HIVDR for a specific population in Dar es Salaam are being mapped. In this JOINT project, two partners of KU Leuven and two Tanzanian partners will join forces to use these system maps of causes ...