Understanding the evolutionary dynamics of phage lysin configurations as a driver for new enzyme-based antibiotics Ghent University
(Bacterio)phage lysins are developed as enzyme-based antibacterials with an outstanding potential to fight antibiotic resistance. The lead lysin is currently evaluated under a clinical phase III trial. What sets apart lysins from all other classes of antibacterials is their modularity and the opportunities that emerge thereof to customize their antibacterial properties. Lysins therefore represent a true new class of antibacterials. Increasing ...