Biosynthesis and bioengineering of novel bacterial benzolactone enamide anti-cancer agents KU Leuven
The oximidines are unusual macrocyclic metabolites that were recently identified from Pseudomonas baetica bacteria and shown to have potent anti-cancer activity. They belong to the benzolactone enamide family of natural products, which inhibit tumor cell proliferation by selectively targeting mammalian vacuolar-type ATPases. Identification and analysis of the oximidine biosynthetic gene cluster has revealed a hybrid polyketide-nonribosomal ...