Projects
Noninvasive imaging of stem cells to evaluate therapeutic efficacy in muscular dystrophy animal models. KU Leuven
Stem cells have a huge potential for regenerative medicine as they are able to differentiate towards various cell types and can be expanded to cell numbers sufficient for therapy. However, despite their huge potential results after clinical translation have been mostly disappointing. Therefore, new methods need to be developed to optimize stem cell therapy for using stem cells at their maximum capacity. At present, cells are injected and ...
Interventional X-ray system equipped with 3D rotational angiography for cardiovascular research in preclinical large animal models. KU Leuven
Current strategies for early treatment of acute coronary
syndromes (i.e. heart attacks) have improved acute survival
but subsequent heart failure and arrhythmias (sudden
cardiac death) are the long-term cause of mortality and
morbidity. Responsible use of large animals as preclinical
translational models remains a cornerstone in
cardiovascular research
and play an irrefutable role in exploratory and ...
Understanding the role of toxic alfa-synuclein protein aggregation as therapeutic target in synucleinopathy animal models KU Leuven
As the global average lifespan increases, age-related brain diseases like Parkinson’s Disease (PD), Multiple System Atrophy (MSA) and Dementia with Lewy Bodies become more common. These progressive diseases are incurable and eventually lead to death. Strategies to slow disease progression are therefore urgently needed. The three diseases are characterized by the abnormal accumulation of a protein called α-synuclein (α-syn) inside brain cells. ...