Projects
IgE-independent drug-induced anaphylaxis, MRGPRX2, basophils and mast cells: connecting the dots. University of Antwerp
Drug-induced anaphylaxis via MRGPRX2 occupation: introduction of a new human model. University of Antwerp
Study of the involvement of various vasodilator mechanisms in systemic inflammation and anaphylaxis Ghent University
Primary mast cell disorders with and without anaphylaxis: a search for specific biomarkers. University of Antwerp
Stepwise Heat-Denaturated protein introduction for tolerance induction in food allergy and pediatric Eosinophilic Esophagitis (TEHITI) KU Leuven
Children with cow’s milk allergy (CMA) who accidentally have cow’s milk intake, can show symptoms varying from eczema exacerbation, urticaria & angio-oedema, gastro-intestinal and respiratory complaints to (potentially fatal) anaphylaxis. To reduce this risk, children and parents receive personal treatment action plans with medication eg adrenalin auto-injectors. Medical care, buying cow’s milk free food alternatives, as well as those ...
Impacts of nitrogen deposition in the natural environment on pollen allergy in Belgium KU Leuven
We hypothesize that increased environmental nitrogen deposition affects plant diversity and plant productivity. These changes may affect airborne pollen distribution, abundance, and allergen potency. Therefore, environmental nitrogen deposition can directly and indirectly have an impact on aeroallergens and the prevalence and severity of allergenic diseases (figure 1). The general objective of this project is to understand how environmental ...
Iron deficiency anaemia in pregnancy: Evaluation of the effectiveness and safety of intravenous ferric carboxymaltose and oral ferrous sulphate in a low-middle income country Institute of Tropical Medicine
Mechanisms and Diagnosis of Mast Cell and Basophil Activation in Rare Hypersensitivity Disorders KU Leuven
Hypersensitivity is an exaggerated response of the immune system to harmless triggers. In Type I hypersensitivity or allergy, effector cells (mast cells and basophils) are activated through allergen-induced cross-linking of surface-bound allergen-specific IgE antibodies, leading to degranulation and systemic release of inflammatory mediators. This can result in a potentially life-threatening rapid-onset clinical syndrome affecting the ...