Publications

The synthesis of pyrimidine unsaturated keto and exomethylene arabinopyranonucleoside analogs as potential antitumor and antiviral agents is described. Commercially available 1,2,3,4-tetra-O-acetyl-d-arabinopyranose (1) was condensed with silylated thymine, uracil, 5-fluorouracil, N(4)-benzoyl cytosine and 5-(trifluoromethyl)uracil, respectively, deacetylated and acetylated to afford 1-(3,4-O-isopropylidene-α-d-arabinopyranosyl)pyrimidine ...

Human beta-defensins (hBDs) are crucial peptides for the innate immune response and are thus prime candidates as therapeutic agents directed against infective diseases. Based on the properties of wild-type hBD1 and hBD3 and of previously synthesized analogs (1C, 3I, and 3N), we have designed a new analog, 3NI, and investigated its potential as an antimicrobial drug. Specifically, we evaluated the antimicrobial activities of 3NI versus those of ...

Toekomstige 4G draadloze communicatiesystemen maken het mogelijk om als consument transparant te kunnen genieten van tal van diensten zoals mobi ele telefonie, draadloos internet, multimedia en lokalisatietoepassingen . De nieuw te ontwikkelen toestellen moeten daarom niet alleen voldoen a an klassieke eisen zoals minimaal vermogenverbruik, oppervlakte en kost. Ze zullen ook de communicatie moeten voorzien via meerdere standaarden. Enkel door de ...

Het onderwerp van deze thesis is de studie van de analoge en RF performantie van ongedopeerde dubbele gate MOSFETs, ook bekend als FinFETs. Dit device is een mogelijk alternatief voor de planaire bulk MOSFET, omwille van zijn betere elektrostatische controle en hogere immuniteit voor kort-kanaal effecten, en een lagere variabiliteit en betere schaalbaarheid naar toekomstige generaties. In dit werk worden de DC, de laagfrequent analoge en de ...

Today's trend in mobile electronics towards smaller and lighter devices conflicts with the other market-driven interest for larger displays. Large displays can improve the user-friendliness of the devices. By using flexible and rollable displays made in organic electronics technology, small devices with large displays are enabled. In this technology a flexible plastic foil is used as the substrate for the electronic circuits. Asa result, the ...

We report the preparation of 2'-alpha-F, 2'-beta-F and 2',2'-difluoro analogues of the leading anti-varicella zoster virus (VZV) pentylphenyl BCNA Cf 1743. VZV thymidine kinase showed the highest phosphorylating capacity for the beta-fluoro derivative, that retained equal antiviral potency as the parent compound. In contrast, the alpha-fluoro- and 2',2'-difluoro BCNA derivatives were markedly less ( approximately 100-fold) antivirally active.

Het werkingsmechanisme van antivirale nucleoside analogen berust op hun metabole conversie naar de corresponderende nucleoside trifosfaten (NTPs), die dan als competitieve inhibitoren of als chain terminators de virale nucleïnezuur synthese inhiberen. Nucleoside fosfonaten kunnen worden beschouwd als bioisosteren van de gebruikelijke nucleotide monofosfaten. In tegenstelling tot nucleoside fosfaten, zijn nucleoside fosfonaten stabiel met ...

The frog skin-derived peptide Temporin 1Tb (TB) has gained increasing attention as novel antimicrobial agent for the treatment of antibiotic-resistant and/or biofilm-mediated infections. Nevertheless, such a peptide possesses a preferential spectrum of action against Gram-positive bacteria. In order to improve the therapeutic potential of TB, the present study evaluated the antibacterial and antibiofilm activities of two TB analogs against ...

In multitarget drug design, it is critical to identify active and inactive compounds against a variety of targets and antitargets. Multitarget strategies thus test the limits of available technology, be that in screening large databases of compounds vs a large number of targets, or in using in silica methods for understanding and reliably predicting these pharmacological outcomes In this paper, we have evaluated the potential of several in ...