Projects
Mold-active Azoles: Development, Validation and Implementation of strategies for Safe and Effective Dosing (M-ADVISED) KU Leuven
Infections, including severe bacterial infections and invasive fungal infections, are a major cause of morbidity and mortality in critically ill patients and other patient populations (i.e. patients with hematological malignancies). Therapeutic exposure to antibacterial or antifungal drugs at the site of infection (or in plasma as a surrogate matrix) is crucial for successful treatment of severe bacterial and fungal infections. However, it ...
A juvenile pig model for pharmacokinetic studies of renally excreted drugs in critically ill children Ghent University
Recent reports demonstrated that critically ill pediatric patients with sepsis often suffer augmented renal clearance (ARC). This leads to subtherapeutic plasma concentrations of renally excreted drugs and possible treatment failure. A juvenile pig model mimicking ARC will be developed to evaluate the pharmacokinetics of two frequently used antimicrobials (amoxicillin-clavulanic acid and amikacin) and to unravel the mechanism of ARC
Improving detection of drug-resistant tuberculosis (TB by use of novel phenotypic and genotypic tests Institute of Tropical Medicine
Pharmacometric models for improved therapeutic drug monitoring of ceftriaxone, posaconazole and infliximab KU Leuven
In clinical drug development, “one dose fits all” is a key objective. However, variability in exposure (E) and response (R) is common and can result in suboptimal treatment of individual patients. To hit a predefined E/R target in each patient, “therapeutic drug monitoring” or TDM is often implemented. TDM helps improving attainment of a desired E/R target by guiding individualised drug dosing based upon drug concentrations. “Population ...
Network-based identification of driver pathways in clonal systems KU Leuven
Highly ethanol-tolerant bacteria for the production of biofuels, bacterial pathogenes which are resistant to antibiotics and cancer cells are examples of phenotypes that are of importance to society and are currently being studied. In order to better understand these phenotypes and their underlying genotype-phenotype relationships it is now commonplace to investigate DNA and expression profiles using next generation sequencing (NGS) and ...