Projects
VIB Grant for de Wit Lab_Period:2022-01-01-2026-12-31 Flanders Institute for Biotechnology
The role of pore forming protein family member Brinp2 in neuron development and function (Beurs voor Marinka Brouwer) Flanders Institute for Biotechnology
On the role of Presenilins in interorganellar communication and Ca2 + handling Flanders Institute for Biotechnology
Cholinergic and noradrenergic neuromodulation of memory and mood. University of Antwerp
Mapping the impact of post-translational modifications on protein aggregation. KU Leuven
A diverse group of principal widespread diseases, including Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS), type II diabetes mellitus and many others, shares a single common feature referring to the constant build-up of protein deposits, which causes various symptoms of growing severity (inflammation, tissue degeneration and full organ disfunction). Aberrant aggregation is promoted by short hydrophobic segments, located within ...
Astroglia and functional brain network disruptions in early AD pathology Flanders Institute for Biotechnology
New neuronal models for intracellular toxic Aß accumulation Flanders Institute for Biotechnology
Unraveling the molecular programs that generate synaptic diversity in the hippocampus. KU Leuven
While the biochemical aspects of Alzheimer's disease (AD) are becoming increasingly unraveled, much less is known about the cellular processes that underlie the gradual transition from prodromal to clinical disease. Emerging evidence suggests that GABAergic interneurons contribute to early circuit dysfunction in AD, but why interneurons might be vulnerable is not understood. Elucidating the pathogenic mechanisms underlying the early stages of ...