Keratinocyte/dendritic cell interactions in the skin determines allergic sensitization and the severity of asthma to house dust mite allergen Ghent University
Asthma is a chronic inflammatory disease of the airways that is seen increasingly in westernalized countries. Studies have shown that a majority of patients with asthma have suffered from atopic dermatitis (AD) in their childhood. Moreover, patients with AD develop more severe steroid-resistant forms of asthma. The mechanisms involved in the progression from AD to asthma are currently unknown. Several reports argue that this might mainly due ...
BASIC: Biomarkers of respiratory Allergy Susceptiblity In Children Hasselt University
The incidence of allergic disease has steadily increased over the past decades, affecting one in ten children in Europe today. It is now understood that a lack of neonatal exposure to antigen of harmless microorganisms, which educate the immune system to discriminate between dangerous and harmless insults, is in part responsible for this phenomenon. In the immune system, certain cell subsets are preferentially generated during early life. ...
Discovery of metabolite biomarkers for early diagnosis and prognosis of cow's milk allergy in children Ghent University
CowU+2019s milk allergy (CMA) is one of the most prevalent and first food allergies to occur in early
childhood. Diagnosis of CMA currently relies on challenge-based tests, which have to be repeated
on a yearly basis to assess possible spontaneous resolution. These tests inherently result in allergic
reactions in patients. As metabolites represent the total contribution of genomic, transcriptomic
and proteomic ...
Mechanisms of the Development of ALLergy (MeDALL) Ghent University
Causes explaining the epidemic of IgE-associated (allergic) diseases are unclear. MeDALL aims at generating novel knowledge on mechanisms of allergy initiation, in particular in childhood. To understand how a complex network of genetic and environmental factors leads to complex allergic phenotypes, a novel stepwise, large and integrative translational approach is needed. MeDALL includes experts in allergy, epidemiology, genetics, immunology, ...
Health effects of exposure to green space, airborne pollen and air pollution A mobile health study on adults with tree pollen allergy KU Leuven
Over the past decades the prevalence of pollen allergy has increased. This trend is expected to continue due to ongoing urbanization, climate change and increasing air pollution. In order to mitigate urban heat and improve air quality in the city, urban green space has been promoted. Urban green spaces have been associated with numerous health benefits. Contact with the natural environment strengthens the human microbiome and immune system. ...
Effect of prebiotics on the development of asthma and allergy. University of Antwerp
Education of lung epithelial cells as an alternative explanation for the protective effect of infectious pressure on development of allergy and asthma. Ghent University
There is an epidemic of allergy and asthma in the Western industrialized world, with up to 30% of children showing reactivity to common inhaled and food allergens. The reason for the increase in these Th2-associated diseases is currently unclear. The hygiene hypothesis of allergy states that lifestyle changes leading to less "infectious pressure" in the first year of life are associated with more allergy. Conversely, growing up on a farm ...
Allergy in a fresh light Ghent University
AlMs of the proposed project
In an attempt to find novel pathways to interfere with the activation of DCs, and thus to come up with
new therapeutic interventions, we are currently focusing on the role that epithelial cells have in
controlling DC activation, as this might be a very drugable pathway due to the exposed position of
epithelial cells to inhaled air and therapeutics carried in it via ...