Projects
An innovative analytical platform to investigate the effect of toxicity of micro and nano plastics combined with environmental contaminants on the risk of allergic disease. KU Leuven
There is an urgent need to understand the risks on human health of micro- and nano-plastic particles (MNPs) that contaminate food and environment. We aim to create a cross-disciplinary platform to design suitable analytical approaches for determining the extent of the problem in the environment and to our health by evaluating the influence of ingested and inhaled exposure of MNPs contaminated with metals, allergens, pathogenic bacteria and ...
Taxonomy, Treatment, Targets and Remission: Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions Hasselt University
TSLP and Ox40L as targets of therapeutic intervention for allergic asthma Ghent University
Epithelial cell derived Thymic Stromal Lymphopoietin (TSLP) instructs dendritic cells (DCs) via the expression of OX40L to induce Th2. TSLP and OX40L are therefore promising targets for the development of new therapies for allergic asthma. The aim of this project is to study the potential of targeting human TSLP and human OX40L for intervening with the initiation and/or progression of allergic asthma, in a humanized mouse model.
Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions KU Leuven
3TR is a transdisciplinary consortium made of experts in all areas of medicine, basic sciences and bioinformatics from academic institutions, SMEs, and 8 major pharmaceutical companies, teamed to study a fundamental issue in medicine: the mechanisms of response and non-response to therapies, the major aim of 3TR, both within single disease entities and across diseases, where molecular stratification may identify shared disease taxonomies. The ...
Post-infectious immune reprogramming and its association with persistence and chronicity of respiratory allergic diseases Ghent University
The central hypothesis of the Predicta project is that repeated, acute infection-mediated events may reprogram the innate, adaptive or regulatory immune responses to predipose towards a chronic inflammation pattern.
The role of specific agents will be sought in order to develop innovative diagnostics for predicting disease chronicity, as well as interventions that may delay or prevent disease progression/persistence.
"Identification of the Molecular Mechanisms of nonresponse to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions’ — ‘3TR’" Flanders Institute for Biotechnology
Mechanisms of the Development of ALLergy (MeDALL) Ghent University
Causes explaining the epidemic of IgE-associated (allergic) diseases are unclear. MeDALL aims at generating novel knowledge on mechanisms of allergy initiation, in particular in childhood. To understand how a complex network of genetic and environmental factors leads to complex allergic phenotypes, a novel stepwise, large and integrative translational approach is needed. MeDALL includes experts in allergy, epidemiology, genetics, immunology, ...