Role of dendritic cell- and airway epithelial cell- specific overexpression of the endogenous danger signal HMGB1 in allergic asthma Ghent University
Asthma is a chronic inflammatory disease of the airways that is seen increasingly in westernalized countries. Airway dendritic cells (DC) and epithelial cells play a crucial role in the process of allergic sensitization to house dust mite (HDM), leading to asthma. The nature of this crosstalk is complex but involves endogenous danger signals like uric acid or ATP, which are released upon stress or cell death and act as adjuvants to promote ...