Projects
Induction of IgA2 class switching in human Ige+B cells as theraphy for allergic disease Ghent University
Abstract (max. 60 woorden): IgE plays a central role in allergy by activating mast cells and facilitating allergen presentation to Th2 lympghocytes. Accumulating evidence suggests that IgA plays a protective role in allergy by antagonizing the effects of IgE. Therefore using three proven IgA promoting regimens: IL-21+TGFB1, cholera toxin B (CTB) and Lactococci engineerd to express allergen and CTB
Diesel and particulate matter as catalysators of allergen induced airway disease: investigation into the role of alarmins and the inflammasome. Ghent University
The in vivo role of alarmins and the inflammasome in diesel exhaust particles-induced (allergic) airway inflammation will be investigated with mice models, by expression analysis and studies with knockout mice and blocking antibodies.
IMPORTANCE AND INTERACTION OF ALLERGY, INFECTIONS AND RESPIRATORY ENVIRONMENTAL EXPOSURES IN CHRONIC LOWER & UPPER AIRWAY DISEASES (AIREWAY II consortium) Ghent University
AIREWAY II, we will further unravel the mechanisms by which allergens, environmental pollutants and microbial agents initiate lower and upper airway diseases and modulate disease persistence. We hypothesize that the following mechanisms -modulated by environmental triggers- play a crucial role in the development of airway diseases: Transient Receptor Potential (TRP)-channels, damage associated molecular patterns (DAMPs), Pattern Recognition ...
Importance and interaction of allergy, infections and respiratory environmental exposures in chronic lower & upper airway diseases (AIReWAY II consortium) Ghent University
The acronym AIREWAY II (Importance and interaction of Allergy, Infections and Respiratory Environmental exposures in the development and chronicity of lower and upper airWAY diseases) describes the global objective of this project, and builds further on our P6/35 AIREWAY project that was initiated in 2007. With this interuniversity collaboration, we will further unravel the cellular and molecular mechanisms underlying lower (asthma and COPD) ...
Immunomodulation and immunoregulation in chronic inflammatory diseases, including cancer, allergy, asthma Vrije Universiteit Brussel
Importance and interaction of allergy, infections and respiratory environmental exposures in chronic lower & upper airway diseases Ghent University
The acronym AIReWAY describes the global objective of this project. With this interuniversity approach, we want to unravel cellular and molecular mechanisms underlying the upper (rhinitis, sinusitis, nasal polyposis) and lower airway diseases (asthma and COPD). The individual and combined effects of allergens. infections and air pollution on the main cellular and molecular mediators, will be characterized at different phases typing the ...
Importance and interaction of allergy, infections and respiratory environmental exposures in chronic lower & upper airway diseases Ghent University
The acronym AIReWAY describes the global objective of this project. With this interuniversity approach, we want to unravel cellular and molecular mechanisms underlying the upper (rhinitis, sinusitis, nasal polyposis) and lower airway diseases (asthma and COPD). The individual and combined effects of allergens. infections and air pollution on the main cellular and molecular mediators, will be characterized at different phases typing the ...
New molecular intervention technology in airway disease caused by allergy or infection Ghent University
The aim of this project is to develop therapeutic interventions to threat infectious and allergic airway inflammation and to elucidate the mechanisms of action. We will us animal models of Mycobacterium tuberculosis and influenza virus infection as well as animal models for asthma. Altered vaccines, immune interference and in situ RNA delivery represent the core strategies of this project.
MAGE – Modelling of Allelic Gene Expression in health and disease. Ghent University
Studying expression of individual alleles could learn us more about possible molecular causes of diseases such as cancer, yet existing methods are too expensive or yield only incomplete information. In this project we will develop a novel, cheaper and more comprehensive methodology, based on population genetics concepts and statistical modelling, and demonstrate its relevance in a cancer case study.