Projects
Ca2+ signalling in ADPKD: mechanisms and consequences. KU Leuven
Mutations in the genes encoding the polycystin-1 and -2 proteins lead to autosomal dominant polycystic kidney disease (ADPKD), the most common inherited renal disease. Hallmark of the disease is the progressive development of renal cysts that lead to kidney failure. The molecular mechanisms underlying the formation of cysts are of major interest to develop novel strategies for treatment and prevention of ADPKD. Disturbed Ca2+ signaling in ...
Translational research into early stages of Autosomal Dominant Polycystic Kidney Disease (ADPKD) KU Leuven
Autosomal dominant polycystic kidney disease (ADPKD) affects up to
13 million individuals and is the 4th common cause of end-stage
kidney disease worldwide, with a major socio-economic burden and
to date without cure. Although ADPKD has been historically
considered as an “adult-onset” disease, nowadays it is recognized
that the adult presentation of the disease is only the tip of the
iceberg. ADPKD is ...
Cytopenia and Autosomal Dominant Polycystic Kidney Disease (ADPKD) KU Leuven
The genetic basis of ADPKD is well known but the pathogenic role of the polycystins is poorly understood. Apart from the well-known effect of the intrinsic loss of PC-1 and PC-2 on cyst proliferation and growth, an important pathophysiological role is attributed to the immune system, both adaptive and innate. Thus, the infiltration of immune cells may be directly caused by the underlying molecular PKD defects. Recently we have reviewed the ...
Clinical and Fundamental Aspects of Autosomal Dominant Polycystic Kidney Disease (ADPKD) Vrije Universiteit Brussel
ADHD specific sleep intervention to improve sleep, ADHD symptoms and related problems in adolescents with ADHD KU Leuven
Up to 72% of adolescents with ADHD experience sleep problems (Langberg et al., 2017), which are likely to be bidirectionally causally related to increased ADHD symptom impairment (Becker et al., 2019), and causally related to oppositional, depressive symptomatology (Becker et al., 2020) and functional impairments (Langberg et al., 2013). Sleep problems become more prevalent over the lifespan. Thus, reducing sleep problems is an important ...
The added value of multimodal biopsychosocial teleprehabilitation in people undergoing total knee arthroplasty Vrije Universiteit Brussel
A data-driven approach to identifying stress response phenotypes based on affective and physiological markers of vulnerability & their added value to stress prediction in daily life KU Leuven
Advances in wearable technology allow for the continuous assessment of physiological data to get a detailed picture of daily-life dynamics associated with the development of mental illness. Specific physiological state transitions may hold prognostic value in the course of development, treatment, and relapse of mental disorders. Computational modelling of the physiological data is a promising approach in predicting this course. Physiological ...
INCREACE - INCREASING RECYCLED CONTENT IN ADDED VALUE PRODUCTS FOR A RESILIENT AND DIGITIZED CIRCULAR ECONOMY KU Leuven
Increasing the share of recycled plastics in new products is a central aspect of the European Strategy for Plastics, adopted by the European Commission in 2018 as a part of the first Circular Economy Action Plan (2015). One of the main goals of the Strategy is to ensure that by 2025 10 million tonnes of recycled plastics find their way into new products on the EU market , against less than 4 million tonnes in 2016. However, in 2016 only 8.4 ...
Towards PREcision MEdicine for Osteoarthritis: added value of cognitive behavioural therapy for insomnia (the PREMEO trial) KU Leuven
Knee osteoarthritis (KOA) is the leading and fastest increasing cause of disability in older adults. It is a serious health issue related with a high health care utilisation. The first-line KOA management is nonsurgical care, with education and exercise therapy as key elements. Nevertheless, treatment effects of exercise therapy and behavioral pain management on improvements in pain, function and quality of life are small to moderate at ...