The cerebral type 1 cannabinoid receptor as modulator in dopaminergic transmission disorders: addiction and psychosis. KU Leuven
Alcohol addiction is the most common complex psychiatric disorders affecting society. However, the exact signaling pathways and mechanisms underlying the development of alcohol addiction and the relapse propensity are still unclear. Phosphodiesterase 10A (PDE10A) is a dual substrate enzyme highly enriched in striatal medium spiny neurons, where it regulates intracellular signaling processes including dopaminergic transmission. PDE10A is ...