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Propargylamine Amino Acids as Constrained Ne-Substituted Lysine Mimetics Vrije Universiteit Brussel
Herein, alkylated propargylamines are reported as constrained lysine mimetics and constructed in a single step using a copper(I)-catalyzed A3-coupling reaction. Using multiple secondary amines, the reaction allowed the generation of a structurally diverse set of N-Fmoc protected amino acid derivatives. In addition, the A3-reaction was applied on solid phase via the assembly of short model tripeptides. Moreover, the internal alkyne moiety allowed ...
Factors Influencing the Kinetics of Esterification of Fatty Acids over Solid Acid Catalysts KU Leuven
The kinetics of esterification of fatty acids with alcohols over three different solid acid catalysts, viz., large pore zeolite-β (Hβ), micro-mesoporous Fe-Zn double-metal cyanide (DMC), and mesoporous Al-MCM-41, have been reported. Hydrophobicity of these catalysts increases in the order: Al-MCM-41 < Hβ < DMC. The chain lengths of the fatty acid (C 8.0-C18.1) and alcohol (C1-C8) molecules have been varied, and their influence on kinetic ...
Origins of the solvent effect on the propagation kinetics of acrylic acid and methacrylic acid Ghent University
Ethyl acetate synthesis by direct addition of acetic acid to ethylene on a silicotungstic acid catalyst : experimental assessment of the kinetics Ghent University
The kinetics of the ethyl acetate synthesis by direct addition of acetic acid to ethylene on an industrial silicotungstic acid catalyst have been acquired experimentally by systematically varying the operating conditions. This is essential to assess the effects of the operating conditions on reactant conversions, selectivity towards the main product ethyl acetate and side products, i.e. ethanol and diethyl ether. Conversions benefit from ...
Conjugated linoleic and linolenic acid production kinetics by bifidobacteria differ among strains Ghent University
Conjugated linoleic and linolenic acid production kinetics by bifidobacteria differ among strains. Vrije Universiteit Brussel
There is great interest in conjugatedlinoleicacid (CLA) and conjugatedlinolenicacid (CLNA) isomers because of their supposed health-promoting properties. Therefore, the differences in productionkinetics of CLA and CLNA isomers from linoleicacid (LA) and ?-linolenicacid (?-LNA), respectively, by bifidobacteria were investigated. Laboratory fermentations, supplemented with LA or ?-LNA in the fermentation medium, were performed with Bifidobacterium ...
Direct effect of dsRNA mimetics on cancer cells induces endogenous IFN-beta production capable of improving dendritic cell function Ghent University
Viral double-stranded RNA (dsRNA) mimetics have been explored in cancer immunotherapy to promote antitumoral immune response. Polyinosine-polycytidylic acid (poly I:C) and polyadenylic-polyuridylic acid (poly A:U) are synthetic analogs of viral dsRNA and strong inducers of type I interferon (IFN). We describe here a novel effect of dsRNA analogs on cancer cells: besides their potential to induce cancer cell apoptosis through an IFN- autocrine ...
Development of αGlcN(1 <-> 1)αMan-based Lipid A mimetics as a novel class of potent Toll-like Receptor 4 agonists Ghent University
The endotoxic portion of lipopolysaccharide (LPS), a glycophospholipid Lipid A, initiates the activation of the Toll-like Receptor 4 (TLR4)myeloid differentiation factor 2 (MD-2) complex, which results in pro-inflammatory immune signaling. To unveil the structural requirements for TLR4 center dot MD-2-specific ligands, we have developed conformationally restricted Lipid A mimetics wherein the flexible beta GlcN(1 -> 6)GlcN backbone of Lipid A ...
Anti-endotoxic activity and structural basis for human MD-2∙TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(l↔l)αGlcN scaffold Ghent University
Interfering with LPS binding by the co-receptor protein myeloid differentiation factor 2 (MD-2) represents a useful approach for down-regulation of MD-2.TLR4-mediated innate immune signaling, which is implicated in the pathogenesis of a variety of human diseases, including sepsis syndrome. The antagonistic activity of a series of novel synthetic tetraacylated bis-phosphorylated glycolipids based on the GlcN(11)GlcN scaffold was assessed in human ...