The 3D non-native code of secretory protein sorting and targeting (NONACO3D) KU Leuven
Proteins are essential for life in all organisms: they mediate cell signalling and cell division and provide structure/motility to cells and tissues. All proteins are synthesised on cytoplasmic ribosomes as unfolded amino acyl polymers that need to find their correct location in the compartmentalised cell and acquire their native functional state. These processes are very important: protein mislocalisation and misfolding are deleterious and ...