Publications
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The posterior cruciate ligament: a study on its bony and soft tissue anatomy using novel 3D CT technology Ghent University
Impact of fibroglandular tissue distribution and breast shape in voxelized breast models for dosimetry in mammography KU Leuven
Objective.This work proposes to study the impact of different voxelized heterogeneous breast models (gaussian centered - GaussC; gaussian lower - GaussL; and fitted equation patient-based on 3D realistic distribution (Fedonet al2021) - FitPB) for dosimetry in mammography compared to a well-established homogeneous approximation. Influence of breast outer shape also was investigated by comparing semicylindric and anthropomorphic ...
Fluorescence Imaging of 3D Cell Models with Subcellular Resolution KU Leuven
Over the past years, research has made impressive breakthroughs towards the development and implementation of 3D cell models for a wide range of applications, such as drug development and testing, organogenesis, cancer biology, and personalized medicine. Opposed to 2D cell monolayer culture systems, advanced 3D cell models better represent the in vivo physiology. However, for these models to deliver scientific insights, appropriate investigation ...
Computational Analysis of 3D Cellular Forces with Application to in vitro Models in Mechanobiology KU Leuven
The field of tissue engineering, as well as the study of many diseases, relies on in vitro models in which obtaining proper vascularization is key. In the last decades, researchers have discovered that chemical signaling alone cannot guarantee the proper growth of new blood vessels from pre-existing vasculature (angiogenesis). Rather, a combination of chemical and mechanical cues is crucial in vascular biology. Through mechanotransduction ...
Protocols and characterization data for 2D, 3D, and slice-based tumor models from the PREDECT project University of Antwerp
Two-dimensional (2D) culture of cancer cells in vitro does not recapitulate the three-dimensional (3D) architecture, heterogeneity and complexity of human tumors. More representative models are required that better reflect key aspects of tumor biology. These are essential studies of cancer biology and immunology as well as for target validation and drug discovery. The Innovative Medicines Initiative (IMI) consortium PREDECT (www.predect.eu) ...
Influence of head positioning during cone- beam CT imaging on the accuracy of virtual 3D models KU Leuven
OBJECTIVE: Cone beam computed tomography (CBCT) images are being increasingly used to acquire three-dimensional (3D) models of the skull for additive manufacturing purposes. However, the accuracy of such models remains a challenge, especially in the orbital area. The aim of this study is to assess the impact of four different CBCT imaging positions on the accuracy of the resulting 3D models in the orbital area. METHODS: An anthropomorphic head ...
Subject-Specific 3D Models to Investigate the Influence of Rehabilitation Exercises and the Twisted Structure on Achilles Tendon Strains KU Leuven
The Achilles tendon (AT) is the largest tendon of the human body and has a primary role in locomotor activities. The complex structure of the AT includes twisting of three sub-tendons, non-uniform tissue deformations and differential triceps surae muscle forces. The main aim of this study was to investigate the impact of commonly used rehabilitation exercises (walking on heels, walking on toes, unilateral heel rise, heel drop with extended knee ...