Projects
In vitro 3D cell models of healthy and OSTEOpathological ageing bone tissue for implantation and drug testing in a multidisciplinary NETwork Ghent University
OSTEONET aims to (i) build a multidisciplinary research network involving experts of technical and medical disciplines to merge their expertise and exploit possible synergies for the development of reliable and sustainable 3D in vitro cell models of healthy and aged bone tissue and (ii) train a cohort of scientists and technologists in exploiting the model features to increase knowledge on the effects of ageing on bone biology and ...
4D monitoring of neo-tissue growth inside perfused tissue engineering constructs - A model supported contrast enhanced computed tomography approach. KU Leuven
Tissue engineering (TE) is still facing challenges with respect to the quality of its products. Advancing engineering aspects lacking in the field will be crucial in order to tackle these challenges. Bioreactor technology is one of these enabling technologies that helps to obtain high TE product quality as it allows for controlled in vitro formation of 3D neo-tissues (cells + extracellular matrix). As these neotissue are 3D dynamic structures ...
3D quantitative multi-tissue imaging by contrastenhanced nanoct to improve the understanding of the dynamic biological processes of tissue formation . Acronym: connecttify = contrast-enhanced nanoct to visualize tissue formation. KU Leuven
Organs and biological tissues have a spatial heterogeneity. Thus, 2D measurements like histomorphometry only partially reveal the degree of change during tissue formation and integration. As a solution, the applicant proposes the use of nanofocus X-ray computed tomography (nanoCT). It allows 3D visualization at high spatial resolution. However, soft tissue contrast is inherently poor. Therefore, within this project it is the aim to synthesize ...
Towards creation of artificial plant tissue through 3D food printing KU Leuven
The global food market is constantly evolving due the growing demand for food and changing consumer preferences. Public interest in the concept of personalized foods with tailor made flavor and dietary properties is increasing steadily. In response to this, digital technologies such as additive manufacturing (AM, also known as 3D printing) are being considered for designing and fabricating food in a more flexible manner. Recently, an ...
Vacularized Scaffolds via Novel 3D Printing Technology for Tissue Engineering and Tumour Modeling Applications KU Leuven
Single-objective light sheet instrument for fast and highthroughput imaging of 3D tissue KU Leuven
Life is 3D and so it should be studied within a matching
context. Fluorescence microscopy is the gold standard for
the imaging of 3D biological samples, but currently available
instruments are severely challenged to visualize tissues or
tissue models with a reasonable speed, suffer from high
photoxicity, or cannot operate with the multiwell plates
required for high-throughput measurements.We propose to develop a ...
Towards enhanced translational colon-specific in vitro tissue models for assessment of drug disposition, metabolism and safety KU Leuven
The overarching goal of this Ph.D. project is to generate and in-depth characterize suitable colon-specific in vitro models to accurately examine colonic drug disposition, metabolism and assess the safety profile of selected compounds in the colon, with specific focus on reproducibility and scalability for pharmaceutical use. Research activities will include: (1) establishing and characterizing 1 to 2 enhanced translational colon-specific in ...