Projects
Screening platform for therapies for peripheral neuropathies (SCREEN4PN) in induced pluripotent stem cell derived 2D and 3D models (development phase 2). University of Antwerp
Business development of a drug screening Spin-off company based on 2D & 3D human iPSC-derived liver cell models for NASH & (i)DILI. KU Leuven
Screening platform for therapies for peripheral neuropathies (SCREEN4PN) in induced pluripotent stem cell derived 2D and 3D models (extension of development phase 2). University of Antwerp
Exploiting exosomal-miRNA cargo effects on 2D and 3D cell systems and in vivo models of muscle degeneration KU Leuven
Muscular dystrophies are inherited neuromuscular disorders that primarily affect striated muscle, mainly characterized by progressive muscle wasting and weakness, leading to physical disability and a shortened life expectancy. In addition, muscle atrophy can be determined by chronic pathological conditions, including cachexia and sarcopenia. Novel therapeutic approaches aim at ameliorating the disease’s course, even if an etiologic cure has ...
Generation of iPSC-derived 3D neuro-immune cell culture models for study and modulation of neuro-inflammatory processes. University of Antwerp
The IncuCyte S3/Organoid platform for live cell culture imaging and kinetic multiparameter analysis of state-of-the-art 3D organoid models and complex tissue mimics KU Leuven
Advanced nanomaterials for photothermal therapy in 3D cell models KU Leuven
Despite significant advances in cancer therapy, cancer remains a major cause of death worldwide. In the last years, there has been increasing interest in the development of new treatment modalities with reduced side effects for difficult-to-cure cancers. One of the most promising examples is photothermal therapy (PTT), designed to selectively kill cancerous tissue through localized, light-induced thermal stress. The efficiency of this thermal ...
3D stem cell models to study the effect of TREM2 on the hallmarks of Alzheimer’s disease KU Leuven
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of plaques, tangles, en neuroinflammation in the brain. Although many research is already done, no cure exists. In my research, I will aim at develping an in vitro model to study AD. There are indeed some mouse models but they do not mimic the whole human pathology. So there is need to develop a model that shows all the hallmarks of AD. This can be used as a ...
Advanced Nanomaterials for Cancer Phototherapies in 3D Cell Models KU Leuven
Despite significant advances in cancer therapy, cancer remains a major cause of death worldwide. In the last years, there has been increasing interest in the development of new treatment modalities with reduced side effects for difficult-to-cure cancers. Prominent examples are photothermal (PTT) and photodynamic (PDT) therapy, designed to selectively kill cancerous tissue either through localized, light-induced thermal stress or generation of ...