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The goal of this sabbatical is twofold. On one hand I plan to establish new connections with researchers within and outside of Europe that would lead to a new scientific cooperation. On the other hand, I hope to use this time, and the expertise of the colleagues, to complete the works on the current C1-project. The new cooperations will be established via internet with colleagues overseas (e.g. Steven L. Franks at Indiana University ...

Novel approach to the proton's 3D structure. University of Antwerp

Pierre Van Mechelen

Particle Physics Group

In this project, I want to address a crucial problem in modern particle physics, namely the quest for the proton's 3D structure. According to the well-established theory of Quantum Chromodynamics, this building block of all visible matter is a composite particle built from elementary partons: quarks and gluons. Many collider experiments can be successfully described in a simple one-dimensional picture where these partons move in the same ...

Nanoparticle-based targeted delivery of therapeutics against arterial media calcification, a major cardiovascular complication in elderly and patients with chronic kidney disease, diabetes and osteoporosis. University of Antwerp

Anja Verhulst

University College London, Pathophysiology

Arterial media calcification is a severe cardiovascular complication in elderly and patients with chronic kidney disease (CKD), diabetes and osteoporosis. This disease is a master of camouflage by disguising itself as physiological bone mineralization, which makes it extremely difficult to find efficient and safe therapies against it, i.e. without affecting bone metabolism. The more as CKD and osteoporosis patients already suffer from bone ...

Utilising multi-body static simulations to explore the macroevolutionary landscape of perissodactyl locomotion. University of Antwerp

Peter Aerts

University of Liège, Functional Morphology

Horses are one of the most recognisable mammals alive today, yet they have undergone dramatic changes throughout their evolution. In particular, the forelimb has changed from an ancestral, four-toed horse to the modern one-toed species we know today. To understand the story of the horse limb, we must look at them with respect to other members of the order Perissodactyla. For example, tapirs are living relatives of horses which retain four toes ...

Human exposure assessment of persistent and mobile chemicals: an analytical challenge. University of Antwerp

Adrian Covaci

Toxicological Centre

Persistent and mobile chemicals (PMs) are man-made and highly polar organic chemicals. Due to potential risks to the environment and humans, policy needs are currently identified. However, there is limited knowledge on PMs, especially on reliable screening and target analytical methods and human exposure pathways. In order to fill knowledge gaps, this research project aims to develop suitable analytical methods using state-of-art mass ...

Unravelling the impact of astronomical light pollution on individual behaviour in a nocturnal bird. University of Antwerp

Marcel Eens

Behavioural Ecology & Ecophysiology

Astronomical light pollution (ALP) is one of the most pervasive, rapidly-expanding pollutants causing a broad-scale illumination of the nocturnal sky. It infiltrates far into natural areas and fundamentally changes the natural night-time environment (e.g. lunar cycle) which has been consistent in evolutionary history and tightly controls animals' circadian rhythms. With a near-exclusive focus of research on light pollution caused by direct point ...

Unraveling the paradigm of opposing phenotypes due to pathogenic variants in the FBN1 gene. University of Antwerp

Bart Loeys

Medical Genetics (MEDGEN)

Marfan syndrome (MFS) and acromelic dysplasias (AD) are caused by pathogenic variants in the fibrillin-1 (FBN1) gene. Remarkably, whereas MFS is characterized by thoracic aortic aneurysms (TAA), tall stature and arachnodactyly, AD patients present with short stature, brachydactyly, and no aortic involvement. Loss of structural integrity of the microfibrils is proposed as the cause of MFS, while altered protein interactions are thought to be at ...

Understanding the medicalization of Female Genital Mutilation/Cutting (FGM/C) through the optics of the practising community in Egypt. University of Antwerp

Sarah Van de Velde

Assiut University, Centre for Population, Family and Health

In Egypt, female genital mutilation/cutting (FGM/C) is increasingly medicalized (performed by trained health professionals rather than by traditional circumcisers). With the current research proposal, I intend to examine how this medicalization trend relates to overall changes in the practice. In doing so, I intend to develop knowledge on (1) how mothers weigh the different options concerning their daughter's FGM/C (traditional cut, medicalized ...

Cooperation and competition in European defence policy University of Antwerp

Dirk De Bièvre

Ghent University, International Politics

Although European governments have agreed to ad-hoc joint defence procurement programmes and EU-level initiatives to source material from the armaments industry, the European defence market remains characterised by a curious mix of inter-state competition and European cooperation. Why do European countries sometimes engage in European defence cooperation, sometimes in ad hoc inter-state military programmes, and in other instances in the form of ...

Fluorinations with implications: enhancing the potential of biologically and medicinally interesting molecules through targeted fluorine introduction Ghent University

Bruno Linclau

Department of Organic and Macromolecular Chemistry

The process of developing bioactive compounds into drugs is notoriously difficult, costing the pharmaceutical industry years and billions of dollars per drug. The motivation of our research

programme is to develop methodologies to improve and accelerate such efforts. The application encompasses three projects, all focused on improving physical properties of bioactive compounds. It is indeed only a recent but very firm realisation ...

Projects

Sabbatical Anna Kisiel KU Leuven