A single-cell integrative (epi)genomics and transcriptomics atlas of human preimplantation embryogenesis to understand cause and effect of (epi)genome dynamics in the first days of human development KU Leuven
The first cell cycles of human life are commonly subject to genome instability. However, the causes and consequences of the genetic alterations in the cells of the developing embryo remain to be investigated. Also the epigenetic landscape –i.e. modifications to the DNA that do not change the DNA-sequence but which can be heritable and control the expression of genes in the cells– is remodelled during early development of a human embryo. This ...