Publications
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Inverse characterization of the orthotropic and viscoelastic material properties of lightweight plates using full field guided wave propagation data KU Leuven
With the advent of the 21st century, climate change-related issues began to play a crucial role in consumer decisions as well as in company objectives. To reduce carbon dioxide emission rates and increase sustainability, companies started to invest more in the development and implementation of advanced materials. Nowadays, lightweight materials such as fiber reinforced polymer laminates and wooden panels offer an alternative for metallic ...
Sparse Array (Nonlinear) Guided Wave Imaging for Localization of Damage in Composites KU Leuven Ghent University
Passive Ultrasound Localization Microscopy of nanodroplet vaporizations during proton irradiation KU Leuven
Superheated nanodroplets (NDs) were recently proposed for in vivo proton range verification, owing to their ability to vaporize into echogenic microbubbles (MBs) upon exposure to ionizing radiation. In a previous publication, vaporization events were detected with 2D Ultrasound Localization Microscopy (ULM) based on a pulse-echo method. Here, we introduce P-ULM, a passive version of ULM, based on the detection of acoustic signatures emitted by ...
Acoustic Modulation Enables Proton Detection with Nanodroplets at Body Temperature KU Leuven
Superheated nanodroplet vaporization by proton radiation was recently demonstrated, opening the door to ultrasound-based in vivo proton range verification. However, at body temperature and physiological pressures, perfluorobutane nanodroplets (PFB-NDs), which offer a good compromise between stability and radiation sensitivity, are not directly sensitive to primary protons. Instead, they are vaporized by infrequent secondary particles, which ...
Ultrasound‑assisted carbon ion dosimetry and range measurement using injectable polymer‑shelled phase‑change nanodroplets: in vitro study KU Leuven
Methods allowing for in situ dosimetry and range verification are essential in radiotherapy to reduce the safety margins required to account for uncertainties introduced in the entire treatment workflow. This study suggests a non‑invasive dosimetry concept for carbon ion radiotherapy based on phase‑ change ultrasound contrast agents. Injectable nanodroplets made of a metastable perfluorobutane (PFB) liquid core, stabilized with a crosslinked ...
Probabilistic ultrasound C-scan imaging of barely visible impact damage in CFRP laminates KU Leuven Ghent University
Ultrasonic pulse-echo C-scan imaging is a widespread method for detecting and characterizing defects in fiber reinforced polymer composites. However, the accurate assessment of a complex distributed damage cluster, like barely visible impact damage, in multi-layer and heterogeneous composites is not straightforward. For reliably estimating the remaining load carrying capacity and/or remaining useful lifetime of a damaged composite, a proper and ...
Spatiotemporal Distribution of Nanodroplet Vaporization in a Proton Beam Using Real-Time Ultrasound Imaging for Range Verification. KU Leuven
The potential of proton therapy to improve the conformity of the delivered dose to the tumor volume is currently limited by range uncertainties. Injectable superheated nanodroplets have recently been proposed for ultrasound-based in vivo range verification, as these vaporize into echogenic microbubbles on proton irradiation. In previous studies, offline ultrasound images of phantoms with dispersed nanodroplets were acquired after irradiation, ...
Ultrasound-assisted investigation of photon triggered vaporization of poly(vinylalcohol) phase-change nanodroplets: A preliminary concept study with dosimetry perspective KU Leuven
Purpose: We investigate the vaporization of phase-change ultrasound contrast agents using photon radiation for dosimetry perspectives in radiotherapy. Methods: We studied superheated perfluorobutane nanodroplets with a crosslinked poly(vinylalcohol) shell. The nanodroplets’ physico-chemical properties, and their acoustic transition have been assessed firstly. Then, poly (vinylalcohol)-perfluorobutane nanodroplets were dispersed in ...